salvage pathway

sal·vage path·way

the use of preformed purine and pyrimidine bases to synthesize nucleotides.

salvage pathway

Oncology A popular term for a metabolic pathway that uses substrates other than the usual biosynthetic intermediates for a product–eg,
1. The salvage of free purines from the hydrolysis of nucleotides for the generation of new nucleotides, or.
2. The 2º pathway of nucleotide synthesis, in which thymidylate is produced by thymidine kinase from thymidine, rather than the usual path in which deoxyuridylate is methylated by thymidylate synthetase into thymidylate, a pathway utilized by Pts with megaloblastic anemia. See Leucovorin 'rescue. '.
References in periodicals archive ?
Nicotinamide Riboside (NR) is the only form of vitamin B3 from which NAD+ can be generated in a vitamin B1, B2 and B6 independent manner and even though NR is a minor component of vitamin B3, the salvage pathway using NR for the production of NAD+ is expressed in most eukaryotes.
Forodesine hydrocloride is an orally-available transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway enzyme that is essential for the proliferation of T-cells and B-cells.
Ingenuity canonical pathways P value Affected molecules Phototransduction pathway 2.57E-04 ARR3, GRK1, and PDE6D The visual cycle 5.50E-04 RDH11, RDH12 RAR activation 1.00E-03 RDH11, ADCY1, RDH12, and CITED2 Retinoate biosynthesis I 2.69E-03 RDH11, RDH12 Retinol biosynthesis 2.69E-03 RDH11, RDH12 Creatine-phosphate biosynthesis 1.17E-02 CKMT1A/CKMT1B Protein kinase A signalling 1.26E-02 H3F3A/H3F3B, ADCY1, GRK1, and PDE6D NAD biosynthesis III 1.26E-02 Nmnat3 NAD biosynthesis from 1.62E-02 Nmnat3 2-amino-3-carboxymuconate semialdehyde NAD salvage pathway III 1.62E-02 Nmnat3
Adenosine deaminase, an enzyme of purine salvage pathway is found in human tissues.
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steadystate NAD+ levels.
Radu, Nathanson and their colleagues found that an important nucleotide called deoxycytidine triphosphate (dCTP) is produced by two pathways, the de novo pathway and the nucleoside salvage pathway.
Plasmodia were long regarded as being unable to utilise intact exogenous folate (the salvage pathway) for tetrahydrofolate formation.
Although most cells are capable of de novo nucleoside biosynthesis, the cellular nucleotide pool is preferentially maintained via the more energy efficient "salvage pathway" involving recycling and uptake of extracellular hydrophilic nucleosides by specialized integral membrane proteins, termed nucleoside transporters (NTs) (Molina-Arcas et al., 2009).
As a pivotal component of an [NAD.sup.+] salvage pathway, Nampt is also a regulator of the activity of [NAD.sup.+]-dependent enzymes, such as class III histone/protein deacetylases (HDAC).
Vitamer levels, stress Response, Enzyme activity and Gene regulation of Arabidopsis Lines mutant in the pyridoxine/pyridoxamine 5'phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) gene involed in the vitamin B6 salvage pathway.Plant physiology, 145: 985-996.
Sepiapterin increases levels of [BH.sub.2], the oxidized form of [BH.sub.4], which is converted to [BH.sub.4] by dihydrofolate reductase through the salvage pathway (Thony et al.