Forodesine hydrocloride is an orally-available transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway
enzyme that is essential for the proliferation of T-cells and B-cells.
Ingenuity canonical pathways P value Affected molecules Phototransduction pathway 2.57E-04 ARR3, GRK1, and PDE6D The visual cycle 5.50E-04 RDH11, RDH12 RAR activation 1.00E-03 RDH11, ADCY1, RDH12, and CITED2 Retinoate biosynthesis I 2.69E-03 RDH11, RDH12 Retinol biosynthesis 2.69E-03 RDH11, RDH12 Creatine-phosphate biosynthesis 1.17E-02 CKMT1A/CKMT1B Protein kinase A signalling 1.26E-02 H3F3A/H3F3B, ADCY1, GRK1, and PDE6D NAD biosynthesis III 1.26E-02 Nmnat3 NAD biosynthesis from 1.62E-02 Nmnat3 2-amino-3-carboxymuconate semialdehyde NAD salvage pathway
III 1.62E-02 Nmnat3
Nicotinamide (NAM) phosphoribosyltransferase (NAMPT) is a key enzyme involved in nicotinamide adenine dinucleotide ([NAD.sup.+]) salvage pathway
Adenosine deaminase, an enzyme of purine salvage pathway
is found in human tissues.
Manipulation of a nuclear NAD+ salvage pathway
delays aging without altering steadystate NAD+ levels.
Radu, Nathanson and their colleagues found that an important nucleotide called deoxycytidine triphosphate (dCTP) is produced by two pathways, the de novo pathway and the nucleoside salvage pathway
Plasmodia were long regarded as being unable to utilise intact exogenous folate (the salvage pathway
) for tetrahydrofolate formation.
Although most cells are capable of de novo nucleoside biosynthesis, the cellular nucleotide pool is preferentially maintained via the more energy efficient "salvage pathway
" involving recycling and uptake of extracellular hydrophilic nucleosides by specialized integral membrane proteins, termed nucleoside transporters (NTs) (Molina-Arcas et al., 2009).
As a pivotal component of an [NAD.sup.+] salvage pathway
, Nampt is also a regulator of the activity of [NAD.sup.+]-dependent enzymes, such as class III histone/protein deacetylases (HDAC).
Vitamer levels, stress Response, Enzyme activity and Gene regulation of Arabidopsis Lines mutant in the pyridoxine/pyridoxamine 5'phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) gene involed in the vitamin B6 salvage pathway
.Plant physiology, 145: 985-996.
Sepiapterin increases levels of [BH.sub.2], the oxidized form of [BH.sub.4], which is converted to [BH.sub.4] by dihydrofolate reductase through the salvage pathway
(Thony et al.