salvage chemotherapy

sal·vage che·mo·ther·a·py

use of chemotherapy in a patient with recurrence of a malignancy following initial treatment, in hope of a cure or prolongation of life.
Synonym(s): salvage therapy (1)

salvage chemotherapy

A treatment modality consisting of high-dose chemotherapy and bone marrow transplantation for cancer patients who have “failed” one or more protocols. For instance, in Hodgkin lymphoma, 24% of those with long initial remissions survive > 11 years, and thus require further (salvage) therapy (e.g., ABVD—doxorubicin, bleomycin, vinblastine, dacarbazine). Salvage regimens include high-dose chemotherapy (3–10-fold greater than conventional dosage), and may be combined with autologous bone marrow, or peripheral stem cell transplantation. Salvage chemotherapy is problematic as the patients may already be in poor condition, e.g., with severe clinical deterioration; large, bulky, aggressive tumour masses; and multi-drug resistances. Salvage chemotherapy is used in NHL, small cell carcinoma, and Hodgkin lymphoma.

salvage chemotherapy

Oncology A treatment modality consisting of high-dose chemotherapy and BMT, for cancer Pts who have 'failed' one or more protocols. See Heroic therapy.
References in periodicals archive ?
- VANFLYTA[R] (quizartinib) is a FLT3 inhibitor MHLW-approved based on a survival benefit compared to salvage chemotherapy in adult patients with relapsed/refractory FLT3-ITD AML
The QuANTUM-R study demonstrated that quizartinib resulted in a statistically significant improvement in overall survival compared to salvage chemotherapy when patients were selected with the LeukoStrat CDx FLT3 Mutation Assay.
Based on the data from the ADMIRAL trial, treatment with gilteritinib monotherapy versus salvage chemotherapy in adult patients with relapsed or refractory AML with an FLT3 mutation showed that the median Overall Survival for patients who received XOSPATA was 9.3 months compared to 5.6 months for patients who received salvage chemotherapy.
Targeted Hodgkin's lymphoma therapy with the antibody-drug conjugate Brentuximab vedotin (Bv) has proven to be superior to conventional salvage chemotherapy and clinical trials are being conducted to incorporate Bv into frontline therapy that substitutes Bv for alkylating agents to minimize secondary malignancies.
This trial is evaluating the impact that the addition of targeted internalized radiation via Actimab-A to the salvage chemotherapy regimen CLAG-M will have on safety and tolerability, response rates, rates of BMT or bone marrow transplant, PFS or progression-free survival, and OS or overall survival.
Salvage chemotherapy and autologous stem cell transplantation for peripheral T-cell lymphoma: A subset analysis of the Canadian cancer trials group LY.12 randomized phase 3 study.
She was started on salvage chemotherapy with high dose Cytarabine plus Mitoxantrone (high-dose AraC and Mitoxantrone protocol).
Among patients with cisplatin-resistant disease, Feldman and colleagues discuss the ongoing clinical trial of conventional-dose salvage chemotherapy versus high-dose chemotherapy with stem cell support (NCT02375204) and the background literature supporting the need for this important trial.
Hagenbeeket al., "Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma," New England Journal of Medicine, vol.
At this point, he was considered a candidate for high-dose therapy with stem cell transplant if induced into remission and, with this intention, had started salvage chemotherapy with Rituximab/Gemcitabine/Cisplatin/Dexamethasone.