It has been found that the saluretic activity was significant in all three groups when compared with control group.
It has been found that the saluretic activity was significant in all three groups when compared with the control group as determined by one-way ANOVA followed by Bonferroni post hoc test.
Saluretic activity of hydrochlorothiazide with misoprostol was also similar to furosemide.
In the present study, it was demonstrated that 28-day ESAH treatment was effective in inducing an important saluretic and antihypertensive response in 2K1C plus OVT-rats.
On the other hand, an important saluretic effect was evident, especially on the elimination of [Na.sup.+] and [Cl.sup.-] throughout the experimental period.
These effects are associated with an important antioxidant and antinitrosant action, in addition to a significant saluretic effect.
Saluretic, Carbonic Anhydrase Inhibition, and Natriuretic Activity.
The increase of [Na.sup.+], [K.sup.+], and [Cl.sup.-] generated by the aqueous extract of leaves F glumosa caused alkalinization of the urine, showing a strong inhibiting activity of carbonic anhydrase and saluretic. These effects were mainly observed at the dose of 375 dose mg/kg.
glumosa on saluretic and natriuretic activity from 24 h of urine.
Both OA and UA showed potent diuretic activity, and comparable natriuretic and saluretic activity to that of hydrochlorothiazide, suggesting inhibition of [Na.sup.+] and [K.sup.+] reabsorption in the early portion of the distal tubule.
This antihypertensive effect can be attributed mainly to the potent antihyperlipidemic and antioxidant activity, combined with diuretic, natriuretic and saluretic activity, due to inhibition of Na+ and K+ re-absorption in the early portion of the distal tubule.
* The difference is significant compared to the control untreated group Table 4 Diuretic, saluretic and natriuretic activity of oleanolic acid and ursolic acid, compared to the effects of urea and hydrochlorothiazide.