Experts discovered salsalate
curbed tangled knots of toxic protein forming in cells - one of the hallmarks of Alzheimer's.
Results of a Phase 2 clinical trial recently published in the Annals of Internal Medicine indicate that salsalate
treatment provided a significant level of blood sugar control among 286 patients with poorly controlled blood sugar levels.
Stage 1 of TINSAL-T2D (Targeting Inflammation Using Salsalate
in Type 2 Diabetes) evaluated varying doses of salsalate
in 108 participants with type 2 diabetes for 14 weeks.
In an earlier study (201W, scientists found that salsalate
reduced hemoglobin A lc (HbAlc) levels by about 0.
To prevent cachexia we used salsalate
, silibinin, melatonin, glutamate, and fish oil.
Previous studies on this plant yielded a beta-lactamase inhibitor named salsalate
(Yang et al.
Instead, sodium salicylate and other nonacetylated salicylates, including salsalate
, inhibit the activity of the transcription factor NF-[kappa]B (33).
If one decides to use medications, acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDS), ketorolac, piroxicam or salsalate
may be tried first.
For example, frail older adults and those with diminished hepatic or renal function who take salsalate
(Disalcid[R]) require frequent salicylate levels and blood pressure monitoring for safe use.
Researchers in 20 medical centers across the country are enrolling adults with type 2 diabetes who have poorly controlled blood glucose to participate in a clinical study, Targeting Inflammation with Salsalate
in Type 2 Diabetes (TINSAL-T2D).
The nonacetylated salicylates, including salsalate
, magnesium choline trisalicylate, and diflunisal, as well as several of the nonsalicylate NSAIDs, such as low-dose etodolac, low-dose ibuprofen, and nabumetone, are reportedly less toxic to the GI mucosa than the other NS-NSAIDs.
Chen recommends non-acetylated salicylates such as salsalate
(Disalcid) or diflunisal (Dolobid) before jumping to prescription NSAIDs.