salsalate


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salsalate

 [sal´sah-lāt]
an ester formed from two molecules of salicylic acid, used in treatment of rheumatoid arthritis and osteoarthritis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

sal·sa·late

(sal'să-lāt),
A combination of two molecules of salicylic acid in ester linkage. The compound is hydrolyzed during and after absorption to salicylic acid that, like other salicylates, exerts analgesic and antiinflammatory effects.
Farlex Partner Medical Dictionary © Farlex 2012

sal·sa·late

(sal'să-lāt)
A combination of two molecules of salicylic acid in ester linkage.
Synonym(s): salicylsalicylic acid.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
To that end, we have investigated the potential for salsalate to increase production of resolvins and its effect on vascular reactivity and neural endpoints related to diabetic peripheral neuropathy.
The only exception is the nonspecific inhibitor of the NF-[kappa]B signaling salsalate, which has not demonstrated significant clinical effects on its own.
Experts discovered salsalate curbed tangled knots of toxic protein forming in cells - one of the hallmarks of Alzheimer's.
Shoelson, "The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial," Annals of Internal Medicine, vol.
Results of a Phase 2 clinical trial recently published in the Annals of Internal Medicine indicate that salsalate treatment provided a significant level of blood sugar control among 286 patients with poorly controlled blood sugar levels.
The scientists became interested in studying salsalate, after research conducted by Steven Shoelson, M.D., Ph.D., Head of the Section on Pathophysiology and Molecular Pharmacology and Professor of Medicine at Harvard Medical School, identified inflammation as a factor in the development of type 2 diabetes.
Salsalate, used for thousands of years to treat the pain of rheumatoid arthritis caused by inflammation, may potentially treat people with type 2 diabetes.
"Clinical data on type II diabetic humans showed that when aspirin or salsalate (a salicylate precursor) were taken, there was a large drop in circulating free fatty acids," says Gregory Steinberg, associate professor in the Department of Medicine at McMaster University and one of the co-authors of the paper.
These findings are important as a large clinical trial is currently underway testing whether salsalate (a well-tolerated aspirin derivative), can prevent Type 2 diabetes.
Previous studies on this plant yielded a beta-lactamase inhibitor named salsalate (Yang et al.
Instead, sodium salicylate and other nonacetylated salicylates, including salsalate, inhibit the activity of the transcription factor NF-[kappa]B (33).