To that end, we have investigated the potential for salsalate
to increase production of resolvins and its effect on vascular reactivity and neural endpoints related to diabetic peripheral neuropathy.
The only exception is the nonspecific inhibitor of the NF-[kappa]B signaling salsalate
, which has not demonstrated significant clinical effects on its own.
Experts discovered salsalate
curbed tangled knots of toxic protein forming in cells - one of the hallmarks of Alzheimer's.
Shoelson, "The effects of salsalate
on glycemic control in patients with type 2 diabetes: a randomized trial," Annals of Internal Medicine, vol.
Results of a Phase 2 clinical trial recently published in the Annals of Internal Medicine indicate that salsalate
treatment provided a significant level of blood sugar control among 286 patients with poorly controlled blood sugar levels.
The scientists became interested in studying salsalate
, after research conducted by Steven Shoelson, M.D., Ph.D., Head of the Section on Pathophysiology and Molecular Pharmacology and Professor of Medicine at Harvard Medical School, identified inflammation as a factor in the development of type 2 diabetes.
, used for thousands of years to treat the pain of rheumatoid arthritis caused by inflammation, may potentially treat people with type 2 diabetes.
"Clinical data on type II diabetic humans showed that when aspirin or salsalate
(a salicylate precursor) were taken, there was a large drop in circulating free fatty acids," says Gregory Steinberg, associate professor in the Department of Medicine at McMaster University and one of the co-authors of the paper.
Salicylate, in a form called salsalate
, has also shown promise as a treatment for insulin-resistance and type 2 diabetes.
These findings are important as a large clinical trial is currently underway testing whether salsalate
(a well-tolerated aspirin derivative), can prevent Type 2 diabetes.
Previous studies on this plant yielded a beta-lactamase inhibitor named salsalate
(Yang et al.
Instead, sodium salicylate and other nonacetylated salicylates, including salsalate
, inhibit the activity of the transcription factor NF-[kappa]B (33).