The prolonged activity of formoterol is also thought to be due to its lipophilicity, although formoterol is less lipophilic than salmeterol
. Formoterol and arformoterol, which is moderately lipophilic, enters the bilipid cell membrane, where it is retained, with the lipid layer acting as a depot and giving a long-acting effect.
The present study demonstrated that Accuhaler with combination drugs of fluticasone and salmeterol
is significantly effective in improving asthma symptomatology and pulmonary function test results.
Kalberg, "Addition of salmeterol
to low-dose fluticasone versus higher-dose fluticasone: an analysis of asthma exacerbations," The Journal of Allergy and Clinical Immunology, vol.
has been shown to inhibit NF-[kappa]B activation suppressing its translocation to the nucleus .
Half of the children were given Salmeterol
inhalers and half took Montelukast pills over the course of a year.
The long-acting [beta]-agonist salmeterol
inhibited fibroblast-mediated collagen gel contraction in a concentration-dependent manner ([10.sup.-8] ~[10.sup.-6] M; P < 0.05 at concentrations of [10.sup.-7] and [10.sup.-6] M compared to control, Figure 1(a)).
The Optimal Therapy study (8) compared the addition of placebo, salmeterol
or the combination of salmeterol/fluticasone with tiotropium.
However, most of the panelists agreed that the benefits of Advair, which combines salmeterol
with the inhaled corticosteroid (ICS) fluticasone, and Symbicort, which combines formoterol with the ICS budesonide, outweighed the risks when used to treat asthma in adults and adolescents, according to last month's joint meeting of the FDKs Pulmonary-Allergy Drugs Committee, Drug Safety and Risk Management Committee, and Pediatric Advisory Committee.
is a bronchodilator that is designed to be long acting.
An Advisory Committee to the FDA recently unanimously agreed (11 to 0) that GlaxoSmithKline's Advair Diskus[R] 500/50 (fluticasone propionate and salmeterol
inhalation powder) demonstrated a significant reduction in the risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD), the fourth leading cause of death in the US.
Peter Calverley and colleagues carried out a randomised, double-blind trial comparing salmeterol
at a dose of 50 [micro]g plus fluticasone propionate at a dose of 500 [micro]g twice daily (combination regimen), administered with a single inhaler, with placebo, salmeterol
alone, or fluticasone propionate alone for a period of 3 years.