All patients fulfilling American college of rheumatology (ACR) criteria of PSS 20125 were included with positive serum anti-Ro/SSA and/or anti-La/SSB antibody testing and presence of focal lymphocytic sialadenitis with a focus score [greater than or equal to]1 focus/4mm2 (lymphocytic foci containing more than 50 cells/mm2 labial salivary gland biopsy
If the biopsy of the affected organ is difficult, minor salivary gland biopsy
may be an excellent alternative and help in diagnosis [11, 13].
Elevated IgA level is a common finding and is strongly associated with abnormal salivary gland biopsy
[27, 28], while IgG can be detected in half of the pSS patients, especially in those with extraglandular manifestations .
A minor salivary gland biopsy
showed lymphoplasmacytic infiltration with a focus score >2 (Figure 2b).
When clinically indicated minor salivary gland biopsy
was taken just after taking their permission.
Labial salivary gland biopsy
plays an important role in the diagnosis of SS.
The patient who had a complaint of swelling and pain in the cheeks had not accepted salivary gland biopsy
one year ago.
Minor salivary gland biopsy
from lower lip shows focal lymphoid infiltration consistent with Sjogren's syndrome.
Having PSS according to this classification requires four of six criteria, of which at least one to be a positive minor salivary gland biopsy
or elevated titers of SS (A) and/or SS (B) antibodies.
Bencivelli et al., "Minor salivary gland biopsy
and Sjogren's syndrome: comparative analysis of biopsies among different Italian rheumatologic centres," Clinical and Experimental Rheumatology, vol.30, no.6, pp.929-933, 2012.
Diagnostic value of labial minor salivary gland biopsy
for Sjogren's syndrome: a systematic review.
Confirmation of the diagnosis is made by histopathologic evaluation of a labial minor salivary gland biopsy
that shows lymphocytic infiltration.