saliva substitutes

Also found in: Dictionary, Thesaurus.
Related to saliva substitutes: xerostomia, artificial saliva

saliva substitutes

(sa-lye-vasub -sti-toots) ,

Entertainers' Secret

(trade name),


(trade name),


(trade name),


(trade name),


(trade name),


(trade name)


Therapeutic: saliva substitutes
Pregnancy Category: UK


Management of dry mouth or throat, which may occur as a consequence of:
  • Medications (tricyclic antidepressants, antihistamines, anticholinergics),
  • Radiation therapy,
  • Chemotherapy,
  • Sjogren's syndrome,
  • Other illnesses,
  • Emotional factors.


Composition is similar to that of saliva.
Contains electrolytes in a thickening agent (carboxymethylcellulose).

Therapeutic effects

Relief of dry mouth.


Absorption: Minimal with local administration; electrolytes may be minimally absorbed through oral mucosa or with swallowing.
Distribution: Action is primarily local.
Metabolism and Excretion: Unknown.
Half-life: Unknown.

Time/action profile (relief of dry mouth)



Contraindicated in: Hypersensitivity to carboxymethylcellulose, parabens, or other components.
Use Cautiously in: Situations in which absorption of electrolytes may compromise the patient’s condition, such as potassium and magnesium in patients with renal failure or sodium in patients with HF or hypertension.

Adverse Reactions/Side Effects

Fluid and Electrolyte

  • excessive absorption of electrolytes


Drug-Drug interaction

None significant.


Oral (Adults) Spray or apply to oral mucosa as needed.

Availability (generic available)

SolutionMoi-Stir—mint flavor; Mouthkote—citrus flavor: in squirt bottle, pump spray, spray canOTC
Swabs: Packets of 3OTC
Lozenges: Packages of 100OTC

Nursing implications

Nursing assessment

  • Assess patient for xerostomia (dry mouth) or dry throat before and periodically throughout therapy.
  • Assess gingiva and oral mucosa for stomatitis.

Potential Nursing Diagnoses

Impairedoral mucous membrane (Indications)


  • Administer as necessary for xerostomia or dry throat.

Patient/Family Teaching

  • Instruct patient to swish saliva substitute around in mouth after spray or application.
  • Advise patient of the importance of good oral hygiene in addition to the use of saliva substitutes.
  • Emphasize the importance of routine dental examinations throughout course of therapy.

Evaluation/Desired Outcomes

  • Decrease in dry mouth and throat.
Drug Guide, © 2015 Farlex and Partners
References in periodicals archive ?
Saliva substitutes for the treatment of radiation-induced xerostomia--a review.
Physical and biological properties of yam as a saliva substitute. Arch Oral Biol.
Influence of saliva substitute films on the initial adhesion of Candida albicans to dental substrata prior to and after artificial ageing.
The present saliva substitutes are intended to act as a replacement of the mucoadhesive, lubricative and protective function of the natural saliva.
Three of the existing saliva substitutes namely xialine 1, xialine 2 and saliveze were prepared in our laboratory.
These values for saliva substitutes and saliva are shown in Table 2.
Figure 5 clearly shows that surface activity of the saliva substitutes is poor compared to that of natural saliva.
We established that all saliva substitutes studied fall short of the biophysical nature of natural saliva.
So this mucin could be another base material for a promising saliva substitute. There is a need to explore additive combinations of phospholipid enhancers to the mucoadhesive polymers in order to develop more efficient saliva substitutes.