safrole


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to safrole: sassafras oil

saf·role

(saf'rōl),
The methylene ether of allyl pyrocatechol; contained in oil of sassafras, oil of camphor, and various other volatile oils; it is obtained chiefly from oil of camphor by fractional distillation; formerly used as a tonic and carminative; prolonged administration causes fatty degeneration.

safrole

Toxicology
An oily phenylpropene extracted from the root-bark or the fruit of sassafras (Sassafras albidum), as well as camphor and other volatile oils. Once used as a carminative, intestinal tonic, topical antiseptic and pediculoside, it is hepatotoxic, causing fatty degeneration, and is carcinogenic; it is listed by the FDA as unsafe.
Mentioned in ?
References in periodicals archive ?
Safrole continues to be used as a pre-precursor for piperonyl methyl ketone (PMK), though availability has decreased since 2014.
Introduction
The phenylpropanoids safrole, eugenol and cinnamic aldehyde were active with [LC.
Metabolitos activos del genero Piper contra Aedes aegypti: fuentes alternativas naturales para el control de vectores de dengue
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
Assessment of genotoxicity of herbal medicinal products: a coordinated approach
A traditional method of Cinnamomum carolinense preparation eliminates safrole from a therapeutic Pohnpean tea.
Symposium review: drug discovery, development and clinical research in academia
When used as a tea, it has none of the safrole content that makes the essential oil carcinogenic.
Herbs to keep you moving: CoreyPine Shane helps you get off the couch and stay warm this winter
5); 4-Allyl-1,2-dimethoxybenzene (1); and 1-Allyl-3,4-methylene dioxy benzene, safrole (1).
EU commission proposes new drinks additives limit
Caffeic acid in coffee, acrylamide in French fries, safrole in black pepper, certain pesticides, PCBs, dioxins, and some fluorinated compounds fall into this category.
Panic in the pantry: a few thoughts on carcinogenicity
Marine fragrance has been produced from safrole extracted from sassafras trees grown in southern China and Vietnam.
Ube Industries to Install Full-scale Marine Fragrance Production System at Its Ube Chemical Plant
Sassafras has been used in folk medicine for centuries, but tests done on laboratory animals found that rats given large doses of safrole developed tumors.
Brew better soda at home: make your own root beer, ginger ale and grape soda with these easy recipes
verum, for example, contains a significant amount of anethole, and safrole is either absent or is found in only trace amounts in this species.
AHPA files comments to FDA's economic analysis of proposed cGMPs; responds to FDA's advisory on star anise teas
albidum bark contains safrole, [Alpha]-pinene, [Alpha]-phellandrene, camphor, and eugenol, which are phytotoxic (Gant and Clebsch 1975).
Host preferences of Rhus radicans (Anacardiaceae) in a southern deciduous hardwood forest

Medical browser ?
Full browser ?