safrole


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Related to safrole: sassafras oil

saf·role

(saf'rōl),
The methylene ether of allyl pyrocatechol; contained in oil of sassafras, oil of camphor, and various other volatile oils; it is obtained chiefly from oil of camphor by fractional distillation; formerly used as a tonic and carminative; prolonged administration causes fatty degeneration.
Farlex Partner Medical Dictionary © Farlex 2012

safrole

Toxicology
An oily phenylpropene extracted from the root-bark or the fruit of sassafras (Sassafras albidum), as well as camphor and other volatile oils. Once used as a carminative, intestinal tonic, topical antiseptic and pediculoside, it is hepatotoxic, causing fatty degeneration, and is carcinogenic; it is listed by the FDA as unsafe.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Genotoxic Effects of Eugenol, Isoeugenol and Safrole in the Wing Spot Test of Drosophila Melanogaster.
Belgium requires and enforces strong reporting requirements for the import and export of precursor chemicals (bulk pseudoephedrine, ephedrine, safrole oil and benzyl methyl ketone), and the Belgian Federal Police have the lead role in enforcing these controls.
For food flavorings, the only class of compounds with usage restrictions by regulatory bodies to some of its constituents is the extraction solvent class, where the agaric acid, aloin, beta-azarone, berberine, coumarin, hydrocyanic acid, hypericin, pulegone, quassine, safrole and isosafrole, santonin and tuyona alpha and beta have maximum tolerable limits discriminated in documents (Brasil, 1999; Brasil, 2007).
Its psychoactive effects could be attributed to metabolic formation of amphetamine derivatives from its core ingredients, elemicin, myristicin, and safrole. (11), (12)
Presence of phenolic compounds like hydroxychavicol and safrole, and phytochemicals like tannins, gallic acid, catechin, []-sitosterol, gum and amino acids have been reported in betel nut (Wang et al., 1997; Duke, 1992).
The roots make a delicious tea that tastes like root beer--be aware that the FDA considers the consumption of sassafras root to be a health hazard due to the presence of safrole. Dig the roots from 2- to 4-foot saplings.
1 NUTMEG contains many essential volatile oils like myristicin, elemicin and safrole, which give a sweet aromatic flavour to nutmeg.
"Mexico could be rapidly becoming a producer of ecstasy, as evidenced by the 2,500 liters of safrole (a tree extract used to produce ecstasy) that were seized at the Mexico City airport in 2011," said the agency, which is based in The Hague in the Netherlands.