safrole


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Related to safrole: sassafras oil

saf·role

(saf'rōl),
The methylene ether of allyl pyrocatechol; contained in oil of sassafras, oil of camphor, and various other volatile oils; it is obtained chiefly from oil of camphor by fractional distillation; formerly used as a tonic and carminative; prolonged administration causes fatty degeneration.

safrole

Toxicology
An oily phenylpropene extracted from the root-bark or the fruit of sassafras (Sassafras albidum), as well as camphor and other volatile oils. Once used as a carminative, intestinal tonic, topical antiseptic and pediculoside, it is hepatotoxic, causing fatty degeneration, and is carcinogenic; it is listed by the FDA as unsafe.
References in periodicals archive ?
Safrole continues to be used as a pre-precursor for piperonyl methyl ketone (PMK), though availability has decreased since 2014.
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
A traditional method of Cinnamomum carolinense preparation eliminates safrole from a therapeutic Pohnpean tea.
When used as a tea, it has none of the safrole content that makes the essential oil carcinogenic.
5); 4-Allyl-1,2-dimethoxybenzene (1); and 1-Allyl-3,4-methylene dioxy benzene, safrole (1).
Caffeic acid in coffee, acrylamide in French fries, safrole in black pepper, certain pesticides, PCBs, dioxins, and some fluorinated compounds fall into this category.
Marine fragrance has been produced from safrole extracted from sassafras trees grown in southern China and Vietnam.
Sassafras has been used in folk medicine for centuries, but tests done on laboratory animals found that rats given large doses of safrole developed tumors.
verum, for example, contains a significant amount of anethole, and safrole is either absent or is found in only trace amounts in this species.
albidum bark contains safrole, [Alpha]-pinene, [Alpha]-phellandrene, camphor, and eugenol, which are phytotoxic (Gant and Clebsch 1975).