soluble fms-like tyrosine kinase 1

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soluble fms-like tyrosine kinase 1

,

sFlt-1

An antiangiogenic protein found in the serum of women who subsequently develop preeclampsia. It may contribute to the development of this syndrome.
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References in periodicals archive ?
In addition to VEGF as the dominant mediator, the soluble receptor sFlt-1 and interleukins also play an important role.4 In accordance with the fact that the pathophysiological process is not sufficiently defined; there is no specific treatment, so the therapy is primarily symptomatic.5 The results of the studies that deal with the effects of severe OHSS on the outcome of pregnancies are controversial.6,7 The purpose of this study was to examine the risk of preterm birth in female patients with the severe form of OHSS.
Studies have speculated that this leads to placental hypoxia, reduced placental perfusion, and the consequent release of placental soluble factors such as soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) (11,12).
One more mechanism can be that the Anti-angiogenic soluble VEGFR1 (SFlt-1) gets elevated and inhibits the action of VEGF by binding free VEGF and rendering it inactive.
Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induced proteinuria.
Furthermore, thymoquinone plays an important role in sFLT-1 synthesis, which triggers VEGF to bind its receptor on endothelial cells.
The recent studies have shown that Pra can lower the blood pressure and improve proteinuria in some preeclampsia-like rodent models including the reduced uteroplacental perfusion pressure (RUPP)-induced rat model and the anti-angiogenic factor-soluble fms-like tyrosine kinase (sFlt-1)-induced mouse model or the complement component 1Q deletion.[1],[2],[3] The results of a clinical pilot study conducted by Brownfoot et al .[4] included four cases; the results showed that the application of Pra might affect the alleviation of the development of preeclampsia.
Serum concentrations of angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) are associated with coagulopathy among patients with acute pancreatitis.
In particular, fine coordination among placental growth factor (PlGF), vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) is important for normal placental development and trophoblast invasion (4-6).
In amniotic fluid, increased vascular endothelial growth factor (VEGF), placental growth factor (PGF), and decreased soluble VEGF receptor-1 (sFlt-1) at 16-19 weeks of gestation, which were indicating angiogenesis and tendency for inflammation, were predictive for PB [65].
**+PlGF+PAPP- A+ADAM-12 sFlt-1 0.54 (0.48-0.59) Myatt et al.
Reduced expression of antiangiogenic proteins such as VEGF receptor-2 (VEGFR-2), endothelial cell tyrosine kinase receptor Tie-2, and soluble fms-like tyrosine kinase 1 (sFlt-1) in syncytiotrophoblastic cells from PAS cases compared to normal placenta specimens suggests a proangiogenic phenotype [19].