ryanodine receptor


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Related to ryanodine receptor: ryanodine receptor 1

ryanodine receptor

receptor associated with a calcium conductance channel in the sarcoplasmic or endoplasmic reticulum of cells, which when bound to ryanodine, causes the channel to remain in a subconductive state, allowing slow continuing release of calcium ions from the sarcoplasmic reticulum into the cytoplasm. The channels are normally sensitive to calcium ions and not sensitive to inositol triphosphate.

ry·an·o·dine re·cep·tor

(rī-an'ō-dēn rĕ-sep'tŏr)
Receptor associated with a calcium conductance channel in the sarcoplasmic or endoplasmic reticulum of cells, which, when bound to ryanodine, causes the channel to remain in a subconductive state, allowing slow continuing release of calcium ions from the sarcoplasmic reticulum into the cytoplasm. The channels are normally sensitive to calcium ions and not sensitive to inositol triphosphate.

ryanodine receptor

Abbreviation: RyR
The release channel for calcium ions that is found on the membranes of the sarcoplasmic reticulum of skeletal muscles.
See also: receptor
References in periodicals archive ?
Faure et al., "Null mutations causing depletion of the type 1 ryanodine receptor (RYR1) are commonly associated with recessive structural congenital myopathies with cores," Human Mutation, vol.
Bidasee, "Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum [Ca.sup.2+]-ATPase (SERCA2) in diabetes," Molecular and Cellular Biochemistry, vol.
Shibata, "Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus," Brain Research.
Lukyanenko, "Distribution of ryanodine receptors in rat ventricular myocytes," Journal of Muscle Research and Cell Motility, vol.
Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.
Santoro et al., "Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor," Circulation Research, vol.
FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure.
Okabe, "Superoxide anion radical-triggered Ca2+ release from cardiac sarcoplasmic reticulum through ryanodine receptor Ca2+ channel," Molecular Pharmacology, vol.
The first evidence of S-nitrosation involvement in this class of pathologies involves the S-nitrosation, and the subsequent hyperactivation, of the [Ca.sup.2+] release channel ryanodine receptor 1 (RyR1).
In sections on herbicides, fungicides, and insecticides, they examine such classes as triazine herbicides, imidazolinone herbicides, morpholine fungicides for treating powdery mildew, avermectin insecticides and acaricides, phenylpyrazole-containing fiprole insecticides, and pyrazolylpyridine activators of the insect ryanodine receptor.
Mainly, neurotoxins bind to surface membrane receptors (sites), but many peptides penetrate the cell membrane and activate components at its cytosolic interface; for example, maurocalcine and imperatoxin A penetrate the membrane bilayers and activate the intracellular ryanodine receptor to provoke the intracellular sequestrated calcium release [31-35].