This will be accomplished by developing transgenic mice with fluorescent labels on four dyadic proteins (L-type calcium channel, ryanodine
receptor, sodium-calcium exchanger, SERCA), and by imaging tissue from explanted normal and failing human hearts.
And the researchers found BPS and BPA had similar effects in quickly and temporarily increasing the phosphorylation of calcium-handling proteins, including ryanodine
receptor and phospholamban.
Identification of a mutation in porcine ryanodine
receptor associated with malignant hyperthermia.
Rycals target the Ryanodine
Receptor (RyR), an intracellular calcium release channel that becomes leaky in disease states including Duchenne Muscular Dystrophy, contributing to muscle damage and loss of function.
Cyantraniliprole, also called Cyazypyr[TM], is in the anthranilic diamide group of insecticides that disrupt the functioning of ryanodine
The protein, known as the Ryanodine
Receptor (RyR), provides the pulse of calcium release that is required for each heart muscle cell to contract.
Ca2 +s are released primarily through the ryanodine
(RyR) and inositol 3-phosphate (InsP3) receptors.
2+] from sarcoplasmic reticulum by activation of 1,4,5-triphosphate inositol and ryanodine
receptors (Imtiaz et al.
The precise control of this movement relies on the direct physical interaction between a calcium channel protein ryanodine
receptor (RYR), and a calcium-sensing protein called calmodulin.
The researchers found that certain intracellular calcium channels known as ryanodine
receptors are likely responsible for mobilizing calcium from LDCVs to facilitate vasopressin release.
Molecular cloning and expression of cDNAs encoding type 2 ryanodine
In sections on herbicides, fungicides, and insecticides, they examine such classes as triazine herbicides, imidazolinone herbicides, morpholine fungicides for treating powdery mildew, avermectin insecticides and acaricides, phenylpyrazole-containing fiprole insecticides, and pyrazolylpyridine activators of the insect ryanodine