ryanodine


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ry·an·o·dine

(rī-an'ō-dēn),
An alkaloid obtained from Ryania speciosa (family Flacourtiaceae); has a disruptive effect on calcium storage in cardiac and skeletal muscle, where it produces sustained contractions; used as an insecticide.
References in periodicals archive ?
Treatment with statins compromised gatekeeper proteins called ryanodine receptors, which control calcium release from storage compartments in muscle cells, leading to spontaneous and irregular calcium leaks that could trigger signals promoting cell death.
Volatile anaesthetics have some cardioprotective and neuroprotective potentials due to ATP-dependent potassium channels, ryanodine receptors and G proteins (15).
The intracellular [Ca.sup.2+]-cycling proteins located in the sarcolemma and sarcoplasmic reticulum (SR), such as the L-type [Ca.sup.2+] channel, SR [Ca.sup.2+]ATPase (SERCA2a), phospholamban (PLB), calsequestrin (CSQ), ryanodine receptor (RYR), and Na+/[Ca.sup.2+] exchanger (NCX), are important in the regulation of myocardial contraction and relaxation by controlling calcium transient homeostasis (12,13).
Ryanodex (dantrolene sodium) is a well-characterized ryanodine receptor antagonist that inhibits intracellular calcium overload secondary to different triggers.
Ca2+ responses of pulmonary arterial myocytes to acute hypoxia require release from ryanodine and inositol trisphosphate receptors in sarcoplasmic reticulum.
Under normal steady-state conditions, the amount of [Ca.sup.2+] released from the SR via the ryanodine receptors (RyRs) is exactly equal to the amount of [Ca.sup.2+] pumped back up into the SR via the SERCA pump.
M2 EQUITYBITES-September 6, 2018-ARMGO Pharma wins US FDA's orphan drug designation for ARM210/S48168 for Ryanodine Receptor Type 1 Related Myopathies
Global Banking News-September 6, 2018-ARMGO Pharma wins US FDA's orphan drug designation for ARM210/S48168 for Ryanodine Receptor Type 1 Related Myopathies
It is mostly transmitted by an autosomal dominant pattern of inheritance over the RyR2 gene encoding the cardiac ryanodine receptor.
Dr Mark Bannister, BHF Cymrufunded researcher at Swansea University, is part of a team studying a protein inside heart cells called the ryanodine receptor.
Dr Mark Bannister, BHF Cymru-funded researcher at Swansea University, is part of a team studying a protein inside heart cells called the ryanodine receptor.