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An alkaloid obtained from Ryania speciosa (family Flacourtiaceae); has a disruptive effect on calcium storage in cardiac and skeletal muscle, where it produces sustained contractions; used as an insecticide.
References in periodicals archive ?
This will be accomplished by developing transgenic mice with fluorescent labels on four dyadic proteins (L-type calcium channel, ryanodine receptor, sodium-calcium exchanger, SERCA), and by imaging tissue from explanted normal and failing human hearts.
And the researchers found BPS and BPA had similar effects in quickly and temporarily increasing the phosphorylation of calcium-handling proteins, including ryanodine receptor and phospholamban.
Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia.
Rycals target the Ryanodine Receptor (RyR), an intracellular calcium release channel that becomes leaky in disease states including Duchenne Muscular Dystrophy, contributing to muscle damage and loss of function.
Cyantraniliprole, also called Cyazypyr[TM], is in the anthranilic diamide group of insecticides that disrupt the functioning of ryanodine receptors.
The protein, known as the Ryanodine Receptor (RyR), provides the pulse of calcium release that is required for each heart muscle cell to contract.
Ca2 +s are released primarily through the ryanodine (RyR) and inositol 3-phosphate (InsP3) receptors.
2+] from sarcoplasmic reticulum by activation of 1,4,5-triphosphate inositol and ryanodine receptors (Imtiaz et al.
The precise control of this movement relies on the direct physical interaction between a calcium channel protein ryanodine receptor (RYR), and a calcium-sensing protein called calmodulin.
The researchers found that certain intracellular calcium channels known as ryanodine receptors are likely responsible for mobilizing calcium from LDCVs to facilitate vasopressin release.
Molecular cloning and expression of cDNAs encoding type 2 ryanodine receptors.
In sections on herbicides, fungicides, and insecticides, they examine such classes as triazine herbicides, imidazolinone herbicides, morpholine fungicides for treating powdery mildew, avermectin insecticides and acaricides, phenylpyrazole-containing fiprole insecticides, and pyrazolylpyridine activators of the insect ryanodine receptor.