RUNX1

(redirected from runt-related transcription factor 1)

RUNX1

A gene on chromosome 21q22.3 that encodes the alpha subunit of core binding factor (CBF), a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is thought to be involved in the development of normal haematopoiesis. 

Molecular pathology
Chromosomal translocations involving RUNX1 are well documented and associated with several types of leukaemia.
References in periodicals archive ?
Runt-Related Transcription Factor 1 (RUNX1), formerly known as AML1 is gene, which encodes alfa subunit of the core binding factor (CBF).
CBFs are four different transcription factors, three DNA binding subunits runt-related transcription factor 1 (Runx1), Runx2, or Runx3 and one non-DNA binding CBF subunit that stabilizes the binding of the subunit to the DNA.
[3] Human genes: RBI, retinoblastoma 1; TP53, tumor protein p53; RUNX1T1, runt-related transcription factor 1, translocated to, 1 (cydin D-related) (formerly EFO); RUNXI, runt-related transcription factor 1; OUG2, oligodendrite lineage transcription factor 2; ERG, v-ets avian erythroblastosis virus E26 oncogene homolog; TMPRSS2, transmembrane protease, serine 2; U2AFI, U2 small nuclear RNA auxiliary factor 1; BCL2, B-cell CLL/lymphoma 2.
Runt-related transcription factor 1 (Runx1) belongs to a small family of transcription factors, including Runx1, Runx2, and Runx3, and is composed of an NH2-terminal DNA-binding runt homology domain followed by a transcriptional activation domain and COOH-terminal negative regulatory domain [12,13].
The Human Genome Organization renamed it as runt-related transcription factor 1 (RUNX1).
It's called RUNX1, which stands for runt-related transcription factor 1.
[3] Human genes: RB1, retinoblastoma 1; TP53, tumor protein p53; RUNX1T1, runt-related transcription factor 1, translocated to, 1 (cyclin D-related) (formerly ETO); RUNX1, runt-related transcription factor 1; OLIG2, oligodendrite lineage transcription factor 2; ERG, v-ets avian erythroblastosis virus E26 oncogene homolog; TMPRSS2, transmembrane protease, serine 2; U2AF1, U2 small nuclear RNA auxiliary factor 1; BCL2, B-cell CLL/lymphoma 2.
The RUNX1 gene (runt-related transcription factor 1) [4] is the most frequent target gene of aberrant activity in human leukemias.