round cell sarcoma

round cell sar·co·ma

obsolete term for an undifferentiated malignant neoplasm, believed to be of mesenchymal origin, composed chiefly of closely packed round cells.
Farlex Partner Medical Dictionary © Farlex 2012

round cell sarcoma

(1) A sarcoma (malignant tumour of mesenchymal origin) composed of round cells—e.g., epithelioid sarcoma, biphasic synovial sarcomas, some PEComas. The term is based on its histologic appearance and was used early in the diagnostic workup, before the results of immunohistochemical stains allow it to be slotted into a more specific category.
(2) An obsolete term for a lymphoma with round cells (lymphocytes) and a sarcomatoid stroma.
(3) Round cell tumour, see there. 
(4) Ewing sarcoma, see there.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Andrew tragically died aged just 26 after being diagnosed with small round cell sarcoma.
The others were diagnosed as angiosarcoma, undifferentiated pleomorphic sarcoma, solitary fibrous tumor, low-grade fibromyxoid sarcoma, malignant peripheral nerve sheath tumor, breast phyllodes tumor, round cell sarcoma with CIC rearrangement, neuroblastoma, malignant extrarenal rhabdoid tumor, and myxofibrosarcoma.
Hence a diagnosis of malignant round cell sarcoma was made.12 The differential diag- nosis included PNET, Lymphoma and Rhabdomyosa- rcoma.
Chloe Bigmore, of Laleston, near Bridgend, died aged 14 in 2007 after contracting a rare cancer called desmoplastic round cell sarcoma.
Behavior is largely determined by the amount of round cell sarcoma present.
(13,14) Type II collagen stains the extraskeletal matrix of the small cell regions in EMCS, and has been shown to be useful in distinguishing EMCS from other round cell sarcomas in a small series of limited tumor types.
Moreover, small round cell sarcomas such as Ewing sarcomas are known to be relatively sensitive to chemotherapy and irradiation [18].
They concluded that renal sarcomas with BCOR-CCNB3 gene fusion overlap with CCSK and are in keeping with a "BCOR alteration family" of renal and extrarenal neoplasms which includes CCSK and undifferentiated round cell sarcomas of soft tissue and bone/soft tissue sarcomas with BCOR-CCNB3 gene fusion, all of which are driven by BCOR overexpression and have overlapping clinicopathologic features.
In the present series, round cell sarcomas were more commonly found on lower extremities, which is comparable to that found by Roy et al.
High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. Genes Chromosomes Cancer.
Round cell sarcomas such as Ewing and rhabdomyosarcoma and malignant peripheral nerve sheath tumor were excluded to fulfill the FNCLCC criteria.