rotaviruses


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rotaviruses

Enteroviridae viruses that are the leading recognized cause of diarrhoea-related illness and death in infants and young children. A live attenuated vaccine is available and provides excellent protection against severe rotavirus gastroenteritis. A pentavalent human-bovine reassortant rotavirus vaccine is also available. This protects against the four most prevalent human strains. The name of the virus derives from the wheel-like appearance on electron microscopy.
References in periodicals archive ?
Rotaviruses. In: Knipe DM, Howley PM, Griffin DE, Martin MA, Lamb RA, Roizman B, et al., editors.
Because rotaviruses were P- and G-typed by PCR using VP4- and VP7-specific primers, we further confirmed the presence of rotavirus in samples from nonsecretor patients.
"Unsuccessful attempts to reduce rotavirus infection with this treatment led scientists to group rotaviruses into two classes: 'sialidase-sensitive' and 'sialidase-insensitive' strains," said von Itzstein.
Further study of this and other unusual reassortant rotaviruses may lead to insight on rotavirus evolution.
Sequence analysis of the VP7 and VP4 genes of these strains demonstrated highest nucleotide identity with G10 and P[14] rotaviruses, respectively.
Evolutionary history and global spread of the emerging G12 human rotaviruses. J Virol.
Comparative sequence analysis showed that these 2 rotavirus strains are part of a novel group of rotaviruses.
The VP7 gene from the G3P[9] strains from Malaysia exhibited greatest identity to VP7 genes from animal G3 rotaviruses; identities were 98% and 97% to a raccoon dog rotavirus (RAC-DG5, Japan, 2004) and a feline rotavirus (Australia, 1984), respectively.
RotaTeq is a pentavalent vaccine of the five strains (G1-G4 and P8) reassorted between bovine and human WC3 rotaviruses and attenuated by Vero cell culture.
The genes encoding the outer capsid viral proteins VP7 and VP4 form the basis of classification of group A rotaviruses into G and P genotypes, respectively (6,7).
ROTASIIL contains bovine-human reassortant rotaviruses against the most common rotavirus serotypes (G1, G2, G3, G4, and G9).
After the discovery of rotavirus, several other agents that were earlier associated with animal diarrhea diseases were later discovered to be rotaviruses from their similar morphological characteristics, such as the epizootic diarrhea of infant mice (EDIM) and simian agent 11 (SA 11) [7].