rotavirus infectionVirology RI is usually mild, but may be severe in children ≤ 2 yrs due to intense vomiting Morbidity > 870,000 children < age 5 die of rotavirus infection in developing countries, in contrast to 75 to 150 in the US Epidemiology Transmitted by fecal-oral route Clinical Diarrhea of 2-12 days duration; rotavirus causes 30–60% of gastroenteritis in children, it is a major cause of epidemic and endemic gastroenteritis, including traveler's diarrhea; RI in immunocompromised Pts may disseminate and involve the liver and kidney Management Symptomatic, rehydration Prevention Vaccine. See Astrovirus, Rotavirus vaccine, VP2, VP4, VP6, VP7, West-to-East phenomenon. Cf Norwalk virus.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.