Two of the more common mycotoxins produced by Stachybotrys are roridin E and verrucarin.
Roridin E and Verrucarin A: Roridin E and verrucarin A are macrocyclic trichothecenes produced by the mold genuses Fusarium, Myrothecium, and Stachybotrys (i.
Production of roridin
by Myrothecium raridum in mixed culture.
The toxic compounds in mio-mio macrocyclic trichothecenes, including roridin
A, D, and E, verrucarin A and J, and mycotoxin A (BUSAM et al.
2008: Capacity of blood albumins to bind ochratoxin A and roridin
chartarum are SG (Figure 1), satratoxin H, isosatratoxin F, roridin
E, and verrucarin J.
This novel test detects trichothecene mycotoxins--including satratoxin (G & H), roridin A, roridin L-2, verrucarol and verrucarin A produced by Stachybotrys and other toxic molds.
The ELISA has a quantitation range for roridin A of 0.
The authors presented an interesting pilot serologic investigation for IgG and IgM antibodies to roridin
(a macrocyclic trichothecene mycotoxin produced by Stachybotrys chartarum) and found no elevation of antibodies in the index case, an individual with repeated exposure to a water-damaged building.
The complex trichothecenes, satratoxin and roridin, produced by Stachybotrys chartarum, were found in minute quantities.
Because there are currently no useful biological monitoring techniques to assess exposure to mycotoxins, we conducted a pilot serologic evaluation using a test under development to identify specific IgG and IgM antibodies to roridin (a tricothecene mycotoxin known to be produced by several different fungi including Stachybotrys species).
Although this laboratory testing did yield evidence that individuals may make specific IgG antibodies to roridin, the source of the exposure that led to this response cannot be determined from our data.