In the MOMENTUM trial, patients are randomized to treatment with AXS-07, rizatriptan
, meloxicam, or placebo.
is available as an orally disintegrating tablet.
Rogers, Disposition and Pharmacokinetics of the Antimigraine Drug, Rizatriptan
, in Humans, Drug.
He had a history of tobacco abuse, ischemic stroke, and arterial hypertension and was receiving acetylsalicylic acid, atorvastatin, rizatriptan
, ferrous sulfate, and losartan-hydrochlorothiazide.
Lourenco, "Formulation and evaluation of rizatriptan
Benzoate mouth disintegrating tablets," Indian Journal of Pharmaceutical Sciences, vol.
versus sumatriptan in the acute treatment of migraine.
Recent product introductions from Camber include aripiprazoe (Abilify), lamivudine/zidovudine (Combivir), montelukast (Singulair), pantoprazole (Protonix); raloxifene (Evista), rizatriptan
(Maxalt); sildenafil (Revatio), valsartan (Diovan) and zolmitriptan (Zomig).
This class of medications includes naratriptan, rizatriptan
, eletriptan, sumatriptan, zolmitriptan, almotriptan, and frovatriptan.
The triptan drugs (e.g., sumatriptan, rizatriptan
, eletriptan, and almotriptan), which are used for more severe migraines, promote vasoconstriction and block pain pathways by activating certain serotonin receptors in cranial blood vessels (Bajwa 2012).
Triptans like Sumatriptan and Zolmitriptan are also available as nasal sprays whereas rizatriptan
and zolmitriptan are available as tablets that dissolve in the mouth.
Exposure to rizatriptan
during pregnancy: Post-marketing experience up to 30 June 2004.
To test the hypothesis that placebo and medication treatment-related outcomes would improve progressively as the information provided to subjects varied from negative (indicating 0% chance of receiving active medication) to uncertain (indicating a 50% chance of receiving active medication) to positive (indicating 100% chance of receiving active medication), the investigators randomly assigned 66 adult subjects aged 18 years and older who had experienced episodic migraine in the past 3 years to receive placebo or active treatment with 10 mg of rizatriptan
(Maxalt-MLT) during six migraine attacks.