fibrocystic disease

(redirected from risk of future cancer)

fibrocystic disease

Breast disease
See Fibrocystic disease of breast.
 
Orthopaedics
See Fibrocystic disease of bone.

fibrocystic disease

Chronic cystic mastitis, fibrocystic disease Surgical pathology A common benign disease of the ♀ breast, first seen circa age 40, which presents as diffuse rubbery induration, punctuated by dilated ducts and variably-sized cysts Major patterns Cysts plus fibrosis; sclerosing adenosis; epithelial hyperplasia, which ↑ CA risk. See Ductal intraepithelial neoplasia.
fibrocystic disease
No risk for future cancer: FCD with adenosis–sclerosing or florid, apocrine metaplasia, cysts–macro- or microscopic, ductal ectasia, fibroadenoma, fibrosis, hyperplasia
Minimal risk for future cancer: with glandular 'crowding', ie 2-4 epithelial cells in depth, mastitis, especially periductal, squamous metaplasia
1.5-2-foldrisk of future cancer: with hyperplasia–moderate or florid, solid or papillary or in a papilloma with a fibrovascular core
2-5-foldrisk of future cancer: with atypical hyperplasia–borderline lesion, either ductal or lobular
8-10-fold ≠ risk of future invasive cancer Carcinoma-in-situ
References in periodicals archive ?
Lastly, following the dogma that ALH represents a generalized marker for increased risk of bilateral breast cancer, excising the local lesion theoretically does not decrease a patient's risk of future cancer development, further supporting a more conservative approach to management.
But the Netherlands Cancer Institute in Amsterdam says subfertile women may have to weigh up the extra risk of future cancer against their desire to be mothers.
The researchers found that for people who had Alzheimer's disease at the start of the study, the risk of future cancer hospitalization was reduced by 69 percent compared to those who did not have Alzheimer's disease when the study started.
Following these forms of treatment, hormonal medication is almost always prescribed to reduce the risk of future cancers in the breasts, as well as in other areas of the body.