fibrocystic disease

(redirected from risk of future cancer)

fibrocystic disease

Breast disease
See Fibrocystic disease of breast.
 
Orthopaedics
See Fibrocystic disease of bone.

fibrocystic disease

Chronic cystic mastitis, fibrocystic disease Surgical pathology A common benign disease of the ♀ breast, first seen circa age 40, which presents as diffuse rubbery induration, punctuated by dilated ducts and variably-sized cysts Major patterns Cysts plus fibrosis; sclerosing adenosis; epithelial hyperplasia, which ↑ CA risk. See Ductal intraepithelial neoplasia.
fibrocystic disease
No risk for future cancer: FCD with adenosis–sclerosing or florid, apocrine metaplasia, cysts–macro- or microscopic, ductal ectasia, fibroadenoma, fibrosis, hyperplasia
Minimal risk for future cancer: with glandular 'crowding', ie 2-4 epithelial cells in depth, mastitis, especially periductal, squamous metaplasia
1.5-2-foldrisk of future cancer: with hyperplasia–moderate or florid, solid or papillary or in a papilloma with a fibrovascular core
2-5-foldrisk of future cancer: with atypical hyperplasia–borderline lesion, either ductal or lobular
8-10-fold ≠ risk of future invasive cancer Carcinoma-in-situ
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