rimexolone


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rimexolone

 [rĭ-mek´sah-lōn″]
a corticosteroid used in topical treatment of inflammation following eye surgery and of uveitis affecting the anterior structures of the eye.

antiinflammatory drug 

A drug which inhibits or suppresses most inflammatory responses of an allergic, bacterial, traumatic or anaphylactic origin, as well as being immunosuppressant. They include the corticosteroids (e.g. betamethasone, dexamethasone, fluorometholone, hydrocortisone acetate, loteprednol etabonate, prednisolone, rimexolone, triamcinolone). They are sometimes combined with an antibiotic drug (e.g. betamethasone combined with neomycin or sulfacetamide, dexamethasone combined with neomycin or polymyxin B). Corticosteroids have side effects, such as enhancing the activity of herpes simplex virus, fungal overgrowth, raising intraocular pressure or cataract formation.There are other antiinflammatory drugs that are non-steroidal (NSAID) and have little toxicity. They act mainly by blocking prostaglandin synthesis. These include diclofenac sodium, flurbiprofen sodium, indomethacin, ketorolac, nepafenac and oxyphenbutazone. See immunosuppressants; steroid.
References in periodicals archive ?
Schellmann et al., "Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells," Immunology Letters, vol.
Antibiotic drops were discontinued and replaced by topical corticosteroids, rimexolone 1% (Vexol[TM], Alcon, Fort Worth, Texas) Qid for 2 months.
There are no human eye data for five topical corticosteroids: difluprednate (Durezol), fluorometholone (Flarex, Fluor-OP, FML), loteprednol (Alrex, Lotemax), prednisolone (Econopred), and rimexolone (Vexol).
Loteprednol etabonate and rimexolone are new-generation synthetic steroids, specifically designed to minimise some of the adverse effects of topical steroids.
Topical rimexolone 1% q6h, cyclopentholate q8h, and ciprofloxacin 500mg q12 PO were prescribed with a bandage contact lens to the left eye.
(23) Recientemente se han investigado dos esteroides suaves de ultima generacion, rimexolone al 1% y loteprednol al 0,2%, que han mostrado eficacia en el tratamiento de la CAE y la CAP.
Table 1 Classification of uveitis Type of uveitis Location State of inflammation Anterior Iris Iritis Ciliary body Anterior cyclitis Iris and ciliary body Iridocyclitis Intermediate Vitreous Vitritis Hyalitis Pars planitis Posterior Choroid Choroiditis Retina Retinitis Neuroretinitis Choroid and retina Chorioretinitis Retinochoroiditis Pan-uveitis All of the above All of the above Table 2 Prednisolone acetate 1% Prednisolone sodium phosphate 0.1-0.5% Fluorometholone 0.1% Rimexolone 1% Loteprednol etabonate 0.5% Table 3 Immunosuppressive drugs Table 3 Class Examples Antimetabolites Azathioprine Methotrexate Mycophenolate mofetil Alkylating agents Cyclophosphamide Chlorambucil Antibiotics Cyclosporine Tacromimus Rapamycin Dapsone Adjuvants Bromocriptine Ketoconazole Colchicine
Posroperatively the patient was prescribed rimexolone 1% (Vexol, Alcon, Texas, USA) q6h that was tapered one drop per week for 4 weeks, and ofloxacin 0.3% (Exocin, Allergan, Ireland) q6h for 10 days.