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Pharmacologic class: Miscellaneous and anticholinergic-like agent
Therapeutic class: Antiviral
Pregnancy risk category C
Prevents nucleic acid uncoating during viral cell replication, preventing penetration in host. Also causes dopamine release from neurons.
Syrup: 50 mg/5 ml
Tablets: 100 mg
Indications and dosages
➣ Treatment of influenza type A
Adults: 100 mg P.O. b.i.d.
➣ Prophylaxis of influenza type A
Adults and children older than age 10: 100 mg P.O. b.i.d.
Children younger than age 10: 5 mg/kg P.O. daily. Maximum dosage is 150 mg daily.
• Renal or hepatic disease
• Seizure disorders
• Elderly patients
• Parkinson's disease
• Hypersensitivity to drug or amantadine
Use cautiously in:
• history of seizures or renal or hepatic disease
• pregnant or breastfeeding patients
• children younger than age 1.
• Give several hours before bedtime.
• Start therapy within 48 hours of symptom onset and continue for at least 1 week.
CNS: headache, dizziness, fatigue, depression, insomnia, poor concentration, asthenia, nervousness
GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, dry mouth, anorexia
Drug-drug. Acetaminophen, aspirin: decreased rimantadine peak blood level
Cimetidine: increased rimantadine blood level
• Assess patient's flu symptoms. Notify prescriber if symptoms don't improve within 2 to 3 days.
• Monitor vital signs; watch for hypotension.
• Closely monitor nutritional status and hydration.
• Advise patient to take several hours before bedtime.
• If patient's taking syrup, tell him to use specially marked oral syringe or measuring device to ensure accurate dose.
• Instruct patient to contact prescriber if symptoms don't improve within 2 to 3 days.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, motor function, and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.