rimantadine hydrochloride

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rimantadine hydrochloride


Pharmacologic class: Miscellaneous and anticholinergic-like agent

Therapeutic class: Antiviral

Pregnancy risk category C


Prevents nucleic acid uncoating during viral cell replication, preventing penetration in host. Also causes dopamine release from neurons.


Syrup: 50 mg/5 ml

Tablets: 100 mg

Indications and dosages

Treatment of influenza type A

Adults: 100 mg P.O. b.i.d.

Prophylaxis of influenza type A

Adults and children older than age 10: 100 mg P.O. b.i.d.

Children younger than age 10: 5 mg/kg P.O. daily. Maximum dosage is 150 mg daily.

Dosage adjustment

• Renal or hepatic disease

• Seizure disorders

• Elderly patients

Off-label uses

• Parkinson's disease


• Hypersensitivity to drug or amantadine


Use cautiously in:

• history of seizures or renal or hepatic disease

• pregnant or breastfeeding patients

• children younger than age 1.


• Give several hours before bedtime.

• Start therapy within 48 hours of symptom onset and continue for at least 1 week.

Adverse reactions

CNS: headache, dizziness, fatigue, depression, insomnia, poor concentration, asthenia, nervousness

CV: hypotension

EENT: tinnitus

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, dry mouth, anorexia

Respiratory: dyspnea

Skin: rash


Drug-drug. Acetaminophen, aspirin: decreased rimantadine peak blood level

Cimetidine: increased rimantadine blood level

Patient monitoring

• Assess patient's flu symptoms. Notify prescriber if symptoms don't improve within 2 to 3 days.

• Monitor vital signs; watch for hypotension.

• Closely monitor nutritional status and hydration.

Patient teaching

• Advise patient to take several hours before bedtime.

• If patient's taking syrup, tell him to use specially marked oral syringe or measuring device to ensure accurate dose.

• Instruct patient to contact prescriber if symptoms don't improve within 2 to 3 days.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, motor function, and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

rimantadine hydrochloride

An antiviral drug given orally to treat influenza A.
References in periodicals archive ?
Nursing homes and other facilities providing care for persons at risk for influenza-associated complications should consider using the antiviral agents amantadine hydrochloride or rimantadine hydrochloride for prophylaxis and/or treatment during institutional outbreaks of influenza type A (3).
Clinical trials have documented that amantadine hydrochloride [4,5,6,8,13] and its analog rimantadine hydrochloride [3,5,10,13,12] are effective drugs for the prophylaxis and treatment of influenza A virus infection.