4 Resistance to
rifampicin has become a useful indicator of possible MDR TB because around 90%
rifampicin resistant cases are also resistant to isoniazid.
Percentage of
Rifampicin Resistance Detected by CBNAAT Drug Resistance No.
Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and
rifampicin resistance: Xpert MTB/RIF.
6 The process identifies all the clinically relevant
rifampicin resistance inducing mutations in the RNA polymerase beta (rpoB) gene in the mycobacterium tuberculosis genome in a real time format using fluorescent probes called molecular beacons.
8) Total 21 8 2 31 (100) Table 5: Drug resistance by indirect proportion method (IPM) of 6 isolates Sample Isoniazid
Rifampicin Ethambutol Strepomycin % (n) % (n) % (n) % (n) Biopsy 1 -- -- 1 tissue Total 16.
Rifampicin can effectively overcome CSCR by inducing catabolism of endogenous steroids, however the normal dose 600mg daily has been associated with complications such as hepatotoxicity.
Interestingly, (-)-deoxypergularinine was strongly synergistic with INH and
rifampicin but the synergy with streptomycin was borderline.
8%, respectively) were lower than those to erythromycin and there were no isolates resistant to ofloxacin and
rifampicin.
7% susceptibility to
rifampicin as compared to only 50% in a study carried out in Aga Khan University, Karachi21, making this drug a potential therapeutic option in Northern Pakistan.
Based on these results by all these authors were selected trimethoprim and
rifampicin as selective agents that could add to M17 and Elliker medium, to find a suitable medium that allows the growth and development of Lactococcus species.
Detection of
Rifampicin & Isoniazid Resistance Gene by Conventional PCR Using Suitable Primers
Background: Decreases in the bioavailability of
rifampicin (RFP) can lead to the development of drug resistance and treatment failure.
