A validated high-performance liquid chromatography method for the determination of
rifampicin and desacetyl
rifampicin in plasma and urine.
If NVP is prescribed for patients with TB, the starting dose should be 200 mg twice daily (the lead-in dose of 200 mg daily is omitted) because of enzyme induction by
rifampicin.
Four other probes (R2, R4a, R4b, and R5) are specific for amplicons carrying the most common rpoB mutation that confers
rifampicin resistance.
Rifampicin concentrations were measured by means of precipitation of plasma proteins with a mixture of acetonitrile and methanol.
The following primer pairs were used to sequence rpoB, katG, and pncA gene mutations that confer resistance to
rifampicin, isoniazid, and pyrazinamide, respectively: rpoB (5'-ATCACACCGCAGACGTTG-3', 5'-TGCATCACAGTGATGTAGTCG-3'); katG (5'-CGTCGAAACAGCGGCGCTGA-3', 5'-CAAGCGCCAGCAGGGCTCTT-3'); and pncA (5'-GGCGCACACAATGATCGGTG-3', 5'-GCTTTGCGGCGAGCGCTCCA3').
Efavirenz is the non-nucleoside reverse transcriptase inhibitor of choice with
rifampicin.
Given the high rates of isoniazid resistance in many parts of India (19,20) ethambutol should likely be prescribed in the continuation phase to minimize the risk of
rifampicin resistance especially when there are significant rates of default or non compliance.
First recorded outbreaks of meningococcal disease in the Israel Defence Force: three clusters due to serogroup C and the emergence of resistance to
rifampicin.
Isoniazid and
rifampicin are the most powerful weapons against tuberculosis bacilli, but growing resistance--particularly to isoniazid--may necessitate a different approach for the WHO to meet its goal of an 85% cure of sputum smear-positive cases by 2005.
Tenders are invited for
Rifampicin 450 Mg 1 Tab Plus Inh 300Mg 1 Tab Ethambutol 800Mg 1 Tab Plus Pyazinamide 750Mg 2 Tab
Placing Xpert at POC resulted in increased case detection, same-day initiation in over 80% of new cases, and knowledge of the Mycobacterium tuberculosis strain's susceptibility to
rifampicin on the day treatment is started.
MTB/RIF test sensitivity for
rifampicin resistance was 94.
