ricin

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Related to ricin toxin: anthrax, Anthrax toxin, Botulism toxin

ricin

 [ri´sin]
a phytotoxin in the seeds of the castor oil plant (Ricinus communis), inhalation or ingestion of which causes intoxication, producing superficial inflammation of the respiratory mucosa with hemorrhages into the lungs, or edema of the gastrointestinal tract with hemorrhages.

ri·cin

(rī'sin, ris'in),
A highly toxic lectin and hemagglutin that occurs in castor beans (the seeds of the castor oil plant, Ricinus communis; if ingested, acts as a violent irritant with possibly fatal results, on the respiratory and gastrointestinal mucosa; an N-glycosidase that acts on the GOS subunit of rRNA, halting protein translation.

ricin

Toxicology A toxic vegetable poison from the castor bean plant–Ricinus communis which causes agglutination and fulminant hemolysis at very high dilutions–1/106 Clinical Abdominal pain, nausea, cramps, convulsions, dehydration, hemolysis, cyanosis, renal failure–oliguria, hematuria, circulatory collapse. See Magic bullet.

ri·cin

(rī'sin)
Toxin derived from castor beans that causes inflammation of the gastrointestinal mucosa and the respiratory tract.
[L. ricinus, castor oil plant]

ricin

A highly poisonous substance found in the castor oil bean Ricinis communis .

ri·cin

(rī'sin)
A highly toxic lectin and hemagglutinin that occurs in castor beans (the seeds of the castor oil plant, Ricinus communis); if ingested, acts as a violent irritant with possibly fatal results, on the respiratory and gastrointestinal mucosa.
[L. ricinus, castor oil plant]
References in periodicals archive ?
In the case of a ricin toxin vaccine, clinical efficacy testing of the vaccine is unethical since exposing unvaccinated humans (i.e., placebo-control group) to ricin toxin would be fatal.
The main claims of this patent cover formulations of Soligenix's proprietary thermostabilized ricin toxin vaccine, RiVax.
Originally designed and filled with chemical agents, 155-mm shells were also tested with a ricin toxin fill.
The company's vaccines/biodefense business segment includes active development programs for RiVax, a ricin toxin vaccine candidate; OrbeShield, a GI acute radiation syndrome therapeutic candidate; and SGX943, a therapeutic candidate for antibiotic resistant and emerging infectious disease.
The overall objectives of the contract are to advance the development of Soligenix's thermostabilization technology, ThermoVax, in combination with the company's ricin toxin vaccine, RiVax, as a medical countermeasure to prevent the effects of ricin exposure.
Ricin toxin is a lethal plant-derived toxin and potential biological weapon because of its stability and high potency, and the fact it is readily extracted from by-products of castor oil production.
RiVax is Soligenix's vaccine to protect against exposure to ricin toxin and is currently being evaluated in Phase I human safety and immunogenicity trials, as well as nonhuman primate studies for efficacy.
Biological-threat scenarios included the deadly Bubonic plague and ricin toxins, which--due to ease of production--are constant worries of international governments.
According to Israel, Cordesman wrote, "Syria weaponized botulinum and ricin toxins in the early 1990s, and probably anthrax."