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radioimmunoassay

 (RIA) [ra″de-o-im″u-no-as´a]
a sensitive assay method that can be used for the measurement of minute quantities of specific antibodies or any antigen, such as a hormone or drug, against which specific antibodies can be raised. An assay for a specific hormone uses antihormone antibody produced by injecting the human hormone into an animal, such as a rabbit, and hormone that has been labeled with a radioisotope. These are mixed with the assay specimen and the antigen (hormone) bound to antibody is separated from the unbound antigen by chromatography or other means. Because any hormone in the assay specimen competes with the radiolabeled hormone for antibody binding sites, the amount of hormone in the specimen is inversely proportional to the radioactivity of the bound fraction or directly proportional to the activity of the free fraction. This is the standard method for clinical laboratory measurements of hormones and is also used for therapeutic drug monitoring, drug abuse screening, and other laboratory tests.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

RIA

Abbreviation for radioimmunoassay.
Farlex Partner Medical Dictionary © Farlex 2012

RIA

abbr.
radioimmunoassay
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

RIA

Abbreviation for radioimmunoassay.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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