Breaker, PhD, and his team of experts in microbiology and bioinformatics at Yale University's Howard Hughes Medical Institute study a type of noncoding RNA called a riboswitch
that helps turn genes on and off.
This type of gene-switching sequence is known as a riboswitch
because it appears on the strand of ribonucleic acid (RNA) that is first transcribed from a gene's DNA.
If fluoride builds up to toxic levels in the cell, a fluoride riboswitch
grabs the fluoride and then turns on genes that can overcome its effects," said Breaker.
and TORONTO, March 23 /PRNewswire/ -- BioRelix, pioneers in the discovery and development of Riboswitch
based therapeutic agents, and Dalton Medicinal Chemistry have jointly announced an expansion and renewal of their exclusive worldwide collaboration and agreement to discover and develop new therapeutics.
NEW HAVEN, Connecticut and TORONTO, November 13 /PRNewswire/ -- BioRelix, pioneers in the discovery and development of RiboSwitch
based therapeutic agents and Dalton Medicinal Chemistry, have jointly announced a research collaboration to discover new therapeutics.
Only when this chemical binds to the riboswitch
does the production of CheZ proceed.
Under the agreement, BioRelix will apply its proprietary riboswitch
technology platform to identify compounds with activity against a number of bacterial targets.
When a cell has sufficient lysine, the amino acid binds to the riboswitch
, triggering a structural change that blocks manufacture of the first enzyme in lysine production.
20 Bacterial Riboswitch
Discovery and Analysis (Tyler D.
Until now, most researchers had assumed a single riboswitch
was specific for a single metabolite.
The genetic control that Gallivan designed is called a riboswitch
, a segment of RNA that changes conformation when bound to certain small molecules and then turns genes on or off (SN: 4/10/04, p.
We anticipate that the Series A financing will allow us to file an IND with at least one RiboSwitch
class and advance other compounds targeting different RiboSwitch
classes through late stage pre-clinical development.