riboswitch


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riboswitch

(rī-bō-switsch),
A form of regulatory RNA sensors, with the ability to sense small molecules ranging from amino acid derivatives to vitamins. It plays a role in bacterial gene regulation.
References in periodicals archive ?
Breaker, PhD, and his team of experts in microbiology and bioinformatics at Yale University's Howard Hughes Medical Institute study a type of noncoding RNA called a riboswitch that helps turn genes on and off.
This type of gene-switching sequence is known as a riboswitch because it appears on the strand of ribonucleic acid (RNA) that is first transcribed from a gene's DNA.
If fluoride builds up to toxic levels in the cell, a fluoride riboswitch grabs the fluoride and then turns on genes that can overcome its effects," said Breaker.
and TORONTO, March 23 /PRNewswire/ -- BioRelix, pioneers in the discovery and development of Riboswitch based therapeutic agents, and Dalton Medicinal Chemistry have jointly announced an expansion and renewal of their exclusive worldwide collaboration and agreement to discover and develop new therapeutics.
NEW HAVEN, Connecticut and TORONTO, November 13 /PRNewswire/ -- BioRelix, pioneers in the discovery and development of RiboSwitch based therapeutic agents and Dalton Medicinal Chemistry, have jointly announced a research collaboration to discover new therapeutics.
Only when this chemical binds to the riboswitch does the production of CheZ proceed.
Under the agreement, BioRelix will apply its proprietary riboswitch technology platform to identify compounds with activity against a number of bacterial targets.
When a cell has sufficient lysine, the amino acid binds to the riboswitch, triggering a structural change that blocks manufacture of the first enzyme in lysine production.
Until now, most researchers had assumed a single riboswitch was specific for a single metabolite.
The genetic control that Gallivan designed is called a riboswitch, a segment of RNA that changes conformation when bound to certain small molecules and then turns genes on or off (SN: 4/10/04, p.
We anticipate that the Series A financing will allow us to file an IND with at least one RiboSwitch class and advance other compounds targeting different RiboSwitch classes through late stage pre-clinical development.