RIP

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RIP

Abbreviation for radioimmunoprecipitation.

RIPK1

A gene on chromosome 6p25.2 that encodes a serine/threonine/tyrosine kinase which transduces inflammatory and cell-death signals (necroptosis), triggered in response to the binding of ligands to death receptors, activation of pathogen recognition receptors (PRRs) and DNA damage. Activation of TNFR1 by TNF-alpha family cytokines recruits TRADD and TRAF2 to the receptor; ubiquitination by TRAF2 enhances communication with downstream signal transducers in the mitogen-activated protein kinase (MAPK) and NF-kappaB pathways, activating genes that encode inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappaB activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 form a necroptosis-inducing complex.

RIP

Abbreviation for radioimmunoprecipitation; respiratory inductance plethysmography.
References in periodicals archive ?
Both caspase-dependent and independent cell death pathways have been described for several ribosome-inactivating proteins (Polito et al.
Despite ribosome-inactivating proteins are known for a very long time, the exact mechanism of their toxicity remains unsolved and deserves to be clarified mainly because of their pharmacological use in medicine.
Polynucleotide: adenosine glycosidase activity of immunotoxins containing ribosome-inactivating proteins. J.
Polynudeotide:adenosine glycosidase activity of ribosome-inactivating proteins: effect on DNA, RNA and poly(A).
Cytotoxicity and toxicity to animals and humans of ribosome-inactivating proteins. Mini Rev.
Sequence comparison and phylogenetic analysis by the Maximum Likelihood method of ribosome-inactivating proteins from angiosperms.