ribonucleotide reductase


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ri·bo·nu·cle·o·tide re·duc·tase

a protein complex that converts ribonucleotide diphosphates (NDPs) such as ADP and CDP to 2'-deoxyribonucleotide diphosphates (dNDPs) such as dADP and dCDP. This complex requires thioredoxin, thioredoxin reductase, and NADPH. It is crucial for DNA synthesis.

ribonucleotide reductase

(1) Ribonucleoside-diphosphate reductase, EC 1.17.4.1. 
(2) Ribonucleoside-triphosphate reductase, EC 1.17.4.2.
References in periodicals archive ?
Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogennesis.
Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.
In this study, we report for the first time the effects of these natural compounds on ribonucleotide reductase (RR) metabolism in human HL-60 promyelocytic leukemia cells.
Alberola et al., "Ribonucleotide reductase messenger RNA expression and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients," Clinical Cancer Research, vol.
Data suggest that the role of iron in T cell proliferation is not limited to the regulation of ribonucleotide reductase activity, but also involves other steps in the T cell activation pathways.
Sequencing and amplified restriction fragment length polymorphism analysis of ribonucleotide reductase large subunit gene of the white spot syndrome virus in blue crab (Callinectes sapidus) from American coast waters.
The publication reports that in patients evaluable for prostate-specific antigen (PSA) there were seven PSA responses (reductions of greater than 50%), seven disease stabilizations and one disease progression on this regimen of antisense therapy targeting the R2 component of ribonucleotide reductase combined with docetaxel and prednisone.
(Toronto, Canada) has obtained a patent to protect the company's intellectual property involving a lead anticancer target, the R1 component of ribonucleotide reductase. This patent broadens the protection that Lorus obtained in a patent granted by the United States Patent and Trademark Office in September 2000.
Ribonucleotide reductase catalyzes the critical conversion of ribonucleotides to deoxyribonucleotides in all organisms.
Usama Akram Alalami (The Role of Nitric Oxide in Tumour Biology), Christopher Mayhew (Evaluation of the Anti-Retroviral Activity and Bone Marrow Toxicity of the Novel Ribonucleotide Reductase Inhibitors Trimidox and Diox and Comparison with Hydroxyurea in Murine Acquired Immunodeficiency Syndrome), Elizabeth O'Gara (Investigation into the Activity of Plant Preparation Against Heliobacter Pylori, Causal Agent of Chronic Gastritis and Gastric and Duodenal Ulcer), Gunter Seyffarth (The Expression of INOS and its Control in Human Intrauterine Tissues at Term).
During this time he used kinetic techniques to elucidate the active site chemistry of the non-heme di-iron enzymes, purple acid phosphatase (PAP) and ribonucleotide reductase (RNR).
That enzyme, ribonucleotide reductase, converts the building blocks of RNA into the building blocks of DNA.