Liu et al., "E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide
reductase small subunit M2," Biochemical and Biophysical Research Communications, vol.
Moreover, this test can be performed on serum, rather than tumor tissue as previous ribonucleotide
analogues have required.
Marsden, "The unique N terminus of the herpes simplex virus type 1 large subunit is not required for ribonucleotide
reductase activity," Journal of General Virology, vol.
Osteochondrin S is a natural ribonucleotide
extract of bovine-derived connective tissues (from accredited BSE-free sources) and yeast.
Potent effect of adenoviral vector expressing short hairpin RNA targeting ribonucleotide
reductase large subunit M1 on cell viability and chemotherapeutic sensitivity to gemcitabine in non-small cell lung cancer cells.
Distribution of genes associated to various molecular functions nucleic acid binding (468) nucleotide binding (420) nucleoside phosphate binding (420) ribonucleotide
binding (325) nucleoside binding (305) Note: Table made from pie chart.
Genes connected to p53 signaling, such as the genes encoding tumor protein 53 (TP53) inducible nuclear proteins [TP53 inducible nuclear protein 1 (TP53INP1) and ribonucleotide
reductase regulatory TP53 inducible subunit M2B (RRM2B)], cyclins [cyclin D2 (CCND2) and cyclin D1 (CCND1)], MDM2 proto-oncogene (MDM2), pleomorphic adenoma gene-like 1 (PLAGL1), and DNA-damage regulated autophagy modulator 1 (DRAM1) were also upregulated in CTC-MCC-41 cells.
Recently, Park and colleagues observed that TrxR2 is a novel binding protein for ribonucleotide
reductase small subunit p53R2, which is involved in nuclear and mitochondrial DNA replication and repair, stimulating the enzymatic activity of TrxR in vitro.
Interestingly, several scientific findings support the ayurvedic perspective: (1) there are important structural similarities between sweet (T1R2/T1R3) and umami (T1R1/T1R3) taste receptors, both heterodimers, having one subunit in common ; (2) mice perceive synergistic umami mixtures (glutamate and ribonucleotide
) as tasting sweet ; (3) taste cells coexpress the sweet taste and umami taste receptor subunits (all three T1R subunits) .
NO is also responsible for inhibition of the iron-containing ribonucleotide
reductase that generates deoxy ribonucleotides
A multiple sequence of Dm-Csp1 with 10 related Deinococci-encoded Csps revealed the presence of an additional feature of Csps, two nonspecific RNA-binding sequence motifs , ribonucleotide
motifs 1 and 2 (Figure 1, RNP1 and RNP2).
Marked suppression of the oncogene (M2 subunit of ribonucleotide
reductase)  or exogenous marker (luciferase)  was reported with intravenous delivery of the transferrin-NP.