Sequence analogs of this, like the uagggu, and those containing analogs of uridines, the zebularine (ribonucleoside
of 2-pyrimidinone) that does not have the O4 atom, and the 4-thiouridine ([s.sup.4]U) (Figure 13, 7, 8), in which the sulfur atom cannot develop H-bond, have been prepared.
Ribonucleotide reductase (RR; EC 188.8.131.52) is responsible for the reduction of ribonucleoside
diphosphates into deoxyribonucleoside diphosphates, which are the building blocks for DNA synthesis and repair in all living organisms (Guarino et al.
Nelson et al., "Antileishmanial action of 4-thiopyrazolo(3,4-d)pyrimidine and its ribonucleoside
. Biological effects and metabolism," Biochemical Pharmacology, vol.
INDIGO Biosciences has launched its new MitoVir Platform, assays that evaluate mitochondrial toxicity by examining inhibition of the ribonucleoside
triphosphates that are substrates for the human mitochondrial RNA polymerase (POL-RMT).
Hydroxyurea, which is an inhibitor of ribonucleoside
reductase and is used as a systemic antitumor agent, is frequently used for the treatment of myeloproliferative and hematologic diseases.
Several agents have been used to activate AMPK experimentally, including AICAR (57-aminoimidazole-4-carboxamide ribonucleoside
), metformin, rosiglitazone, resveratrol and other polyphenols, statins, and several adipocytokines.
The s base is an analog of the well-known fluorescent 2-aminopurine base, and the ribonucleoside
of s exhibits fluorescence emission centered at 434 nm by excitation at 352 nm in phosphate buffer (pH 7).
Among their perspectives are inhibiting HIV entry, helicase-primase inhibitors as a new approach to combating herpes simplex virus and varicella zoster virus, alkoxyalkyl ester pro-drugs of antiviral nucleoside phosphate and phosphonates, maribavir as a novel benzimidazole ribonucleoside
for preventing and treating cytomegalovirus diseases, lethal mutagenesis as an unconventional approach to combating HIV, silencing viruses with antiviral RNAi, and neuraminidase inhibitors as anti-influenza agents.
But macrophages do have high levels of a closely related molecule called rNTP (ribonucleoside
triphosphate), which is more versatile and is used in cells in a variety of ways.
NS5B nucleoside inhibitors (NIs) or analogs (NM-107/NM-283, PSI 6130/R7128, IDX184, MK-0608) compete with cellular ribonucleoside
triphospahtes act as functional chain terminators (114).
The primary follicle culture medium was consisted of ribonucleoside
and deoxyribonucleoside-free [alpha]-MEM-glutamax medium supplemented with 1% (v/v) heat-inactivated FBS, 1% (v/v) ITS liquid medium, 100 mIU/ml recombinant human FSH, and 10 mIU/ml LH, to which 0, 5, 10, 50, or 100 [micro]M bME were added.
Importantly, no indication of a requirement for ribonucleoside
di- or tri-phosphates for p26 chaperoning can be found in a variety of in vitro studies (Liang et al., 1997; Viner and Clegg, 2001).