Barois et al., "Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry
and microneme proteins and in parasite division," PLoS Pathogens, vol.
Vaccination studies in mice have focused on the selection of protective antigens and the most promising experimental vaccines now combine proteins from micronemes, dense granules, and rhoptry
organelles that are secreted by the parasite during active invasion of the host cell (7).
Tan et al., "Evaluation of immunoefficacy of a novel DNA vaccine encoding Toxoplasma gondii rhoptry
protein 38 (TgROP38) against chronic toxoplasmosis in a murine model," BMC Infectious Diseases, vol.
kinases are involved in mediating pathogenesis of T.
In Toxoplasma gondii, rhoptry
neck protein 2 (RON2) is the receptor for AMA1 .
(17) On the other hand, DNA vaccine of plasmid encoding the rhoptry
protein 1 gene combined with the genetic adjuvant of pcIFN-[gamma], applied against T.
Entzeroth, "A merozoite-specific 22-kDa rhoptry
protein of the coccidium Eimeria nieschulzi (Sporozoa, Coccidia) is exocytosed in the parasitophorous vacuole upon host cell invasion," Parasitology Research, vol.
Juridical Foundation The Chemo-Sero-Therapeutic Research Institute (Kumamoto-shi, Japan) has patented a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry
of Babesia caballi merozoite.
TgSUB1 is a microneme protein, whereas TgSUB2 localizes to rhoptries and associates with rhoptry
protein ROP1, a potential substrate.