thiosulfate sulfurtransferase

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thi·o·sul·fate sul·fur·trans·fer·ase

[MIM*180370]
a transferase that catalyzes the formation of thiocyanate and sulfite from cyanide and thiosulfate.
References in periodicals archive ?
could produce cynamidehydratase, rhodanese and ss-cyanoalnine synthases, which known to play an important function in reducing the growth of plant pathogenic fungi (Wilmari, 2010).
Obasi, "Diurnal variation of cyanogenic glucosides, thiocyanate and rhodanese in cassava," Phytochemistry, vol.
MSA was used to detect the heterogeneity in the binding of Groel-GroES-ADP with substrate rhodanese [5].
It has further been speculated that the mitochondrial enzyme, rhodanese, that detoxifies cyanide by conversion to thiocyanate is not as abundant in tumor cells as in normal cells, leading to selective tumor cell cyanide poisoning.
The hydrogen cyanide formed enters the bloodstream and is metabolized (detoxified) by the liver enzyme rhodanese or thiosulfate: cyanide sulfur transferase in the presence of sulfur containing amino acids methionine and cysteine, to thiocyanate.
Sulfite is further transferred into thiosulfate by rhodanese. Thiosulfate reductase and sulfite oxidase eventually metabolize thiosulfate into sulfate which is excreted.
(53), (54) [H.sub.2]S is cleared by mitochondrial enzymes such as sulfide-quinone oxidoreductase (SQR), sulfur dioxygenase, and rhodanese. However, the regulation of these enzymes is poorly understood.
The liver enzyme rhodanese or thiosulfate: cyanide sulfur transferase, in the presence of sculpture containing amino acids convert hydrogen cyanide to thiocyanate.
TbHsp70.c and Tbj2 were heterologously expressed and purified and both proteins displayed the ability to suppress aggregation of thermolabile MDH and chemically denatured rhodanese. ATPase assays revealed a 2.8-fold stimulation of the ATPase activity of TbHsp70.c by Tbj2.
An enzyme present in high concentration in normal cells but very low in cancer cells is the enzyme rhodanese or sulfur transferase.
In the body cyanide is detoxified by the enzyme rhodanese, forming thiocyanate, which is excreted in the urine.