could produce cynamidehydratase, rhodanese
and ss-cyanoalnine synthases, which known to play an important function in reducing the growth of plant pathogenic fungi (Wilmari, 2010).
It has further been speculated that the mitochondrial enzyme, rhodanese
, that detoxifies cyanide by conversion to thiocyanate is not as abundant in tumor cells as in normal cells, leading to selective tumor cell cyanide poisoning.
The hydrogen cyanide formed enters the bloodstream and is metabolized (detoxified) by the liver enzyme rhodanese
or thiosulfate: cyanide sulfur transferase in the presence of sulfur containing amino acids methionine and cysteine, to thiocyanate.
Sulfite is further transferred into thiosulfate by rhodanese
2]S is cleared by mitochondrial enzymes such as sulfide-quinone oxidoreductase (SQR), sulfur dioxygenase, and rhodanese
The liver enzyme rhodanese
or thiosulfate: cyanide sulfur transferase, in the presence of sculpture containing amino acids convert hydrogen cyanide to thiocyanate.
An enzyme present in high concentration in normal cells but very low in cancer cells is the enzyme rhodanese
or sulfur transferase.
In the body cyanide is detoxified by the enzyme rhodanese
, forming thiocyanate, which is excreted in the urine.
distribution in porcine (Sus scrofa) tissues.
Monte Carlo molecular modeling approaches indicate that a mushroom-like conformation for dPJ9 yields theoretical scattering data that agrees well with the experimental data, similar to results obtained for rhodanese
Detoxification can also include administration of thiosulfate, which is incorporated into thiocyanate by rhodanese
(a mitochondrial transsulfurase enzyme) and excreted in the urine.