rheumatoid nodule

rheumatoid nodule

A mass in tendons, tendon sheaths, periarticular tissue, serous membranes–pleural, pericardium, meninges, cardiac valves, kidneys, lung parenchyma, skin, spleen, synovium, vessels, viscera, in 20% of Pts with rheumatoid arthritis DiffDx Similar nodules occur in SLE, rheumatic fever. See Rheumatoid arthritis.
References in periodicals archive ?
The relationships between the patients' morning stiffness, functional stages, cigarette smoking, lung involvement, ocular involvement and rheumatoid nodule presence and Fc[gamma] RIII gene polymorphism distributions were investigated.
However RF is found in up to 5% of healthy population as well.11 Seropositivity is associated with rheumatoid nodule formation in approximately 25% of patients as the most common extra- articular manifestation of RA12 and the presence of anti-CCP predicts more aggressive disease13 but seronegative RA can be aggressive as well.
Relapse of cutaneous leishmaniasis in a patient with an infected subcutaneous rheumatoid nodule. Br J Dermatol.
Such a reaction can mimic a rheumatoid nodule. Large tophi may undergo ossification.
Subcutaneous granuloma annulare should be differentiated from rheumatoid nodule, sarcoidosis, infections and tumours.
Table 1: Differential diagnosis: Solitary pulmonary nodule Infectious Granuloma Mycobacteria Fungus Sarcoidosis (rare) Organizing pneumonia Lung abscess (or septic embolus) Round pneumonia Fungal pneumonia Neoplastic Benign Hamartoma Inflammatory (myofibroblastic) pseudotumor Sclerosing hemangioma Granular cell tumor Malignant Bronchogenic carcinoma Solitary metastasis Carcinoid/atypical carcinoid tumor Vascular Arteriovenous malformation Pulmonary infarct Hematoma Pulmonary artery aneurysm Lymphatic Intrapulmonary lymph node Lymphoma Congenital Bronchogenic cyst Inflammatory Rheumatoid nodule Wegener's granulomatosis Airway Mucoid impaction (bronchiectasis) Miscellaneous Rounded atelectasis Amyloidosis
Histologic examination revealed an intramural lesion composed entirely of spindle and epithelioid histiocytes arranged in a palisaded pattern, with central necrosis (Figure 1) similar to the features of a rheumatoid nodule. Necrotic areas consisted mostly of acellular eosinophilic material, but residual spindle ghost cells, arranged in fascicles, were identified in some sections.
In this study, extra-articular feature in rheumatoid arthritis group noted were as follows: Rheumatoid nodule 3(8%), interstitial lung fibrosis 1(2%), ischemic heart disease 2(4%), osteoporosis 3(8%).
[+ or -] SD Disease duration (year) 11.9 0.04-60.0 [+ or -] 9.2 Age of disease onset 42.2 6-82 (year) [+ or -] 13.3 Duration of follow-up 26.7 2-65 (month) [+ or -] 17.8 Diagnostic delay (year) 3.1 0-39 [+ or -] 5.5 Family history 81 18.4 Type of rheumatoid arthritis Erosive 200 59.3 Cystic 137 40.7 Rheumatoid nodule 33 7.5 Extra-articular 95 21.5 involvement Comorbid disease 206 46.7 Rheumatoid factor 262 59.4 positivity SD: Standard deviation; Min.: Minimum; Max.: Maximum.