rheumatoid factors


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Related to rheumatoid factors: RF test

rheu·ma·toid fac·tors (RF),

antibodies in the serum of patients with rheumatoid arthritis. These factors are autoantibodies of the classes IgM, IgG, and IgA. The most common factor is IgM and is the one usually measured. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.

rheu·ma·toid fac·tors

(rū'mă-toyd fak'tŏrz)
Antibodies in the serum of people with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma-globulin; also occur in other autoimmune diseases and certain infectious diseases.

rheumatoid factors

The antibodies (immunoglobulins) present in the blood in cases of RHEUMATOID ARTHRITIS. These are IgM, IgG and IgA autoantibodies to the patient's own IgG.
References in periodicals archive ?
Elevated rheumatoid factor and long term risk of rheumatoid arthritis: a prospective cohort study.
Key Words: Rheumatoid arthritis, rheumatoid factor, anticyclic citrullinated peptide antibody, TNF-[alpha] inhibitors, infliximab
Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations.
Most would agree that complexes of 7s IgG or 19s IgM rheumatoid factors directed against altered 7s IgGs--of self-assembling 7s IgGs (Mannik) activate anaphylatoxins in the joint.
Further adding to diagnostic delay is that patients with IE may have a positive rheumatoid factor in 19% of cases.
False positive troponin I in the MEIA due to the presence of rheumatoid factors in serum.
These multispecific, or polyreactive, antibodies often exhibit properties of autoantibodies, are frequently IgM rheumatoid factor, are more common among neonates, and may be idiotypic antibodies (11,13-15), which is in accord with the idiotypic-antiidiotypic antibody regulatory network theory of Jerne (17).
All five patients were elderly women with high concentrations of serum rheumatoid factor (RhF).
Moreover, in view of the high specificity of these antibodies, the test is particularly useful in differential diagnosis between RA and other arthritides that are clinically similar to RA and may be positive for rheumatoid factor (RF), such as hepatitis C virus (HCV)-associated cryoglobulinemia (6, 7), undifferentiated polyarthritis (8), or Sjbgren syndrome (9, 10).