rhabdomyosarcoma


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rhabdomyosarcoma

 [rab″do-mi″o-sahr-ko´mah]
a highly malignant tumor arising in striated muscle or in embryonal mesenchymal cells that exhibit differentiation along rhabdomyoblastic lines, including but not limited to the presence of cells with recognizable cross striations. The pleomorphic form affects predominantly the skeletal muscles of adults; the embryonal-alveolar form occurs mainly in the skeletal muscles of children and young adults, and the embryonal-botryoid form occurs predominantly in tissues of the head, neck, orbit, and urogenital tract of children and young adults.

rhab·do·my·o·sar·co·ma

(rab'dō-mī'ō-sar-kō'mă),
A malignant neoplasm derived from skeletal (striated) muscle, occurring in children or, less commonly, in adults; classified as embryonal alveolar (composed of loose aggregates of small round cells) or pleomorphic (containing rhabdomyoblasts).
Synonym(s): rhabdosarcoma
[rhabdo- + G. mys, muscle, + sarkōma, sarcoma]

rhab·do·my·o·sar·co·ma

(rab'dō-mī'ō-sahr-kō'mă)
A malignant neoplasm derived from skeletal (striated) muscle, classified as embryonal alveolar (composed of loose aggregates of small round cells) or pleomorphic (containing rhabdomyoblasts).
Synonym(s): rhabdosarcoma.
[rhabdo- + G. mys, muscle, + sarkōma, sarcoma]

rhabdomyosarcoma

A rare and often highly malignant tumour of muscle affecting people at both extremes of life. Treatment is by surgical removal, RADIOTHERAPY and anticancer drugs.

rhab·do·my·o·sar·co·ma

, rhabdosarcoma (rab'dō-mī'ō-sahr-kō'mă, rabdō-sahr-)
Malignant neoplasm derived from skeletal (striated) muscle, occurring in children or, less commonly, in adults.
[rhabdo- + G. mys, muscle, + sarkōma, sarcoma]
References in periodicals archive ?
Out of 49 malignant cases in females, SCC were 14 (27.5%) and the most common lesions followed by BCC 11 (22.5%), Sebaceous Glands Carcinomas 6 (12%), Malignant Melanomas 5 (10%), Basosquamous Carcinomas (8%), Rhabdomyosarcomas (4%), NHLs (4%), dysplasia grade III 2 (4%), round blue cell tumor 1 (2%), Osteogenic sarcoma 1 (2%) and metastatic papillary thyroid carcinoma 1 (2%).
The testing ultimately involved tracking the safety and effectiveness of several promising drug candidates in hundreds of mice with different human rhabdomyosarcoma tumors grown in the muscle.
Rhabdomyosarcoma has a variety of clinical presentations, the most common being a rapidly growing soft tissue mass.
Out of the remaining primary tumors, 42 (24M, 18F) were muscular in origin, all of which were Rhabdomyosarcomas presenting in ages 1.
Most frequent Round Cell Tumors are Non-Hodgkins Lymphoma, Neuroblastoma, Ewing/PNET and Rhabdomyosarcoma. Neuroblastoma, Retinoblastoma, Wilms Tumor, Hepatoblastoma have presentations in early childhood while Rhabdomyosarcoma are seen throughout childhood.
Vestergaard, "Ovarian Sertoli-Leydig cell tumor of intermediate grade with heterologous elements of rhabdomyosarcoma. A case report and a review of the literature," Annals of Diagnostic Pathology, vol.
Total laryngectomy and permanent tracheostomy for treatment of laryngeal rhabdomyosarcoma in a dog.
In terms of molecular and genetic markers of embryonal and alveolar rhabdomyosarcoma, 80-90% of alveolar RMS cases have chromosomal translocations of the DNA-binding domain of PAX3 or PAX7 at 2q35 to the transactivation domain of the FOXO1 gene at t(2;13) (q35;q14) or t(1;13) (p36;q14), respectively [3, 10-14].
This is an advantageous circumstance as these metastatic lesions carry poor prognosis; the overall mean survival is estimated at 7-16 months, with the majority surviving less than 12 months (e.g., Ewing's sarcoma) and a minority surviving more than 12 months (e.g., osteosarcoma, chondrosarcoma, and rhabdomyosarcoma (RMS)) [4].
We reporta case of radiation-induced mucosal melanoma in a 41 -year-old woman with a history of childhood rhabdomyosarcoma of the nasal cavity that had been treated with radiotherapy.
GlobalData's clinical trial report, "Rhabdomyosarcoma Global Clinical Trials Review, H1, 2016" provides an overview of Rhabdomyosarcoma clinical trials scenario.