The intermediate type tends to have a greater number of cells with skeletal muscle differentiation, sometimes with ganglion-cell-like rhabdomyoblasts
The tumor contains primitive mesenchymal cells admixed with a variable content of rhabdomyoblasts
, which demonstrate elongation, more cytoplasmic eosinophilia, and sometimes cross-striation (Figure 13, C).
The spindled morphology of spindle cell rhabdomyosarcomas is differentiated from SFT via the presence of spindle or polygonal rhabdomyoblasts
, as well as diffuse desmin and myogenin expression.
The term rhabdoid' refers to tumour cells that resemble rhabdomyoblasts
morphologically but differ immunohistochemically and ultrastructurally6.
The appearance of the sarocomatous component is that of rhabdomyoblasts
, mature appearing cartilage or chondrosarcoma, osteoid, bone or osteosarcoma and liposarcoma.
Rhabdomyosarcoma (RMS) is a rapidly growing, malignant mesenchymal neoplasm that arises from primitive muscle cells called rhabdomyoblasts
and accounts for 15-20% of all soft tissue sarcomas.
Microscopy confirmed the presence of a high-grade malignant tumour consisting of primitive mesenchymal cells at various stages of myogenesis in the form of rhabdomyoblasts
Phosphotungstic acid haematoxylin is also useful in this scenario, as it stains the rhabdomyoblasts
a deep purple colour.
Rhabdomyosarcoma is a malignant tumor originating from rhabdomyoblasts
that is rarely reported in domestic animals or in free-living and pet birds.
Sections of tumor showed areas of large "giant" multinucleated anaplastic rhabdomyoblasts
, thus making the diagnosis of pleomorphic RMS involving the pericardium and lung pleura.
11) Rhabdomyosarcoma usually affects children and adolescents and the tumors contain characteristic, small, round cells with mitotic activity or have "strap" rhabdomyoblasts
that stain positive for myosin.
Histologically, it bears a close resemblance to various stages in the skeletal muscle embryogenesis: small, round, undifferentiated cells, rhabdomyoblasts
, and myxoid matrix.