According to the company, Dornase alfa is a recombinant human deoxyribonuclease I (rhDNase
I), an enzyme which selectively cleaves deoxyribonucleic acid (DNA).
Recent studies have shown that the use of rhDNase
can reduce airway resistance, improve lung function, inhibit formation of eosinophilic extracellular traps, and halt goblet cell hyperplasia .
Recombinant human deoxyribonuclease (rhDNAse
(Pulmozyme))  and glucocorticoids  are not recommended in the management of infants and children with bronchiolitis.