reward deficiency syndrome

reward deficiency syndrome

A name for a relative failure of the dopaminergic system which plays a major part in brain-reward mechanisms. The syndrome, which has been linked to dysfunction of the D2 dopamine receptors, includes various conditions, such as drug and alcohol abuse, smoking, obesity, pathological gambling and attention deficit hyperactivity disorder, in which the subject seems to be unusually concerned to achieve reward. The D2 dopamine receptor gene is on chromosome 11 and has multiple allelic forms. Variants have been correlated with these and other reward-seeking behaviours.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Finally, some authors argue that the diseases' interaction is mediated by common pathophysiological mechanisms, such as reward deficiency syndrome [13, 20, 22, 23].
Neuro-genetics of reward deficiency syndrome (RDS) as the root cause of "addiction transfer": a new phenomenon common after bariatric surgery.
ADHD can be seen as a reward deficiency syndrome, which is the breakdown of the reward "cascade"-the patient is not getting rewarded by typically rewarding activities, which leads to impulsivity, other clinical correlates, and addictive behaviors.
Dopamine and glucose, obesity, and reward deficiency syndrome. Front Psychol 2014;5:919.
A newer supplement for brain healing is the natural product Synaptamine, developed by Ken Blum, who has been a noted researcher and coined the phrase reward deficiency syndrome to describe the impulsive and compulsive disorders and personality disorders associated with a decrease in dopamine (DRD2) receptors in the brain.
This product is developed by a team of qualified doctors who have studied addiction, genetics, neurological science, Reward Deficiency Syndrome (RDS), and dopamine effects on the brain.
The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. Journal of the Royal Society of Medicine, 89, 396-400.
Other topics include cancer biomarkers, cardiac channelopathies, and the neurogenetics of reward deficiency syndrome.
Researchers have proposed that defects in this system can result in a reward deficiency syndrome and that adults with this syndrome are at higher risk for abuse of psychoactive substances.
Subsequently, in 1995 Blum coined the term "reward deficiency syndrome" (RDS), an umbrella term for behaviors that are associated with genetic antecedents that result in a hypodopaminergic state and a predisposition to obsessive, compulsive and impulsive behaviors (see Table 1).
Researcher Kenneth Blum, PhD, described this as "reward deficiency syndrome." Addicts seek out stimuli to make themselves feel better.