Evaluation of nonsynonymous SNVs confirmed some outbreak viruses to be revertants
of the vaccine AHSV-1 strain toward the virulent parental type.
The reason is simple: With big-data analysis of whole genomes, a comparison of normal, tumor, and revertant
lines has at last opened the possibility of finding mechanisms of reversion, and from there, the possibility of designing drugs to revert tumor cells rather than killing them.
The colonies were counted and the results were expressed as the number of revertant
colonies per plate.
There were no revertants
exceeding three times the background average either with or without the metabolic activation system.
In the experimental design used, the independent variable was the concentration of the samples of the Cauca River and the response variable was the number of spontaneous revertants
of strains in each treatment, with and without enzymatic activation.
In the first AAV-mediated gene therapy trial for this disease, a surprising finding was that hidden epitopes of expressed dystrophin, usually found on revertant
fibres, proved to be immunogenic for some individuals.
Smith FJ, Morley SM, McLean WH: Novel mechanism of revertant
mosaicism in Dowling-Meara epidermolysis buuosa simplex.
After incubation, the number of revertant
bacteria colonies, which signifies mutation events, was counted.
1) An outbreak of poliomyelitis that was due to a revertant
virus (ie, mutated so no longer as attenuated) from oral poliovirus vaccine strain 1 occurred fairly recently in the Dominican Republic and Haiti.
It is likely that reverted oysters would exhibit lower fecundity than diploid oysters because revertant
oysters are mosaic; i.
Given the problems of long-term carriers, revertant
strains, and limitations of surveillance, it is very difficult to certify an area as polio free, even without the possibility that someone may be developing a biological weapon using polio.
We determined if the chimeric flower phenotype would be expressed or become inactivated when crossed to stable pink (wp*) or purple (Wp*) flowered revertant
lines derived from LN89-5320-8-53.