reversible inhibition

reversible inhibition

inhibition of enzyme activity in which the inhibiting molecular entity can associate and dissociate from the protein's binding site.
References in periodicals archive ?
The use of Xerava during the second and third trimester of pregnancy, infancy and childhood up to the age of eight years may cause reversible inhibition of bone growth.
Ticagrelor bound directly, changed the conformation of the P2Y12 receptor, and resulted in a reversible inhibition of the receptor [5].
It requires a local anesthetic and the gel is injected into the lumen and works on the same basis as Reversible Inhibition of Sperm Under Guidance (RISUG).
Anti-inflammatory properties and selective reversible inhibition of human MAO-B by desmethoxyyangonin 6 suggest potential therapeutic use of this kavalactone for treatment of neurodegenerative diseases like Parkinson's disease.
In the recent issue of Nature Chemistry Biology, the IMED team go on to show that it is possible to use a non-catalytic lysine residue in the PPI target, Mcl-1, to achieve covalent reversible inhibition. As lysine is an amino acid commonly found in binding sites across all relevant drug target classes, this is potentially game-changing as it could enable medicinal chemists to design covalent inhibitors for many proteins that would previously have been inaccessible to small molecule drugs.
Lead poisoning also has hematologic consequences (anemia), renal consequences (interstitial nephritis), gastrointestinal symptoms (vomiting, constipation), and endocrine consequences (reversible inhibition of vitamin D metabolism and permanently short stature).
The project was funded by the ministry of Health and Family Welfare and the research was coordinated by the Indian Council of Medical Research Reversible Inhibition of Sperm Under Guidance ( RISUG), now in the last leg of its trials, is slated for a restricted, monitored launch by the end of this year.
RISUG - Reversible Inhibition of Sperm Under Guidance (RISUG) involves injecting a synthetic gel into the vas deferens, the tubes through which sperm travels out of the body.
Lissner's favourite male contraceptive option is called Reversible Inhibition of Sperm Under Guidance (RISUG).
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

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