reversed genetics

reversed genetics

the approach to studying biological systems in which precisely defined lesions are made first in DNA molecules and their phenotypic effects are studied subsequently. This contrasts with the classic genetics approach, in which mutants are isolated first by PHENOTYPE and the nature of the lesions determined afterwards. Reversed genetics has been made possible as a result of RECOMBINANT DNA TECHNOLOGY.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005