reverse transcriptase


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Related to reverse transcriptase: reverse transcription, Reverse transcriptase inhibitors

reverse transcriptase

 [re-vers´ tran-skrip´tās]
an enzyme of RNA viruses that catalyzes the transcription of RNA to DNA, which is then incorporated into the genome of the host cell. This is the reverse of the usual mechanism for replication of genetic information; in the presence of this enzyme it is the RNA that serves as the template for DNA copies. It is one mechanism by which reproduction of cancer cells is facilitated. Called also RNA-directed DNA polymerase.

re·verse tran·scrip·tase

RNA-dependent DNA polymerase, present in virions of RNA tumor viruses (retroviruses).

reverse transcriptase

n.
A polymerase that catalyzes the formation of DNA on an RNA template, found in the retroviruses and in certain other viruses, such as hepatitis B virus.

re·verse trans·crip·tase

(RT) (rē-vĕrs' tran-skrip'tās)
RNA-dependent DNA polymerase, present in virions of RNA tumor viruses.

reverse transcriptase

An enzyme that allows certain viruses, notable HIV, to synthesize double strand DNA from a single strand of RNA so that it can be incorporated into the genome of the host cell. Such viruses are called retroviruses.

reverse transcriptase

an RNA-dependent DNA polymerase that catalyses the synthesis of DNA from deoxyribonucleoside-5′-triphosphate, using RNA as a template.

re·verse trans·crip·tase

(rĕ-vĕrs' tran-skrip'tās)
RNA-dependent DNA polymerase, present in virions of RNA tumor viruses.
References in periodicals archive ?
As shown in Fig 6, the two descriptors (MLOGP and MATS5m) significantly influence the biological magnitude of the inhibition of HIV-1 reverse transcriptase. The first descriptor (MLOGP) correlates positively with biological response (EC50) and describes the hydrophobicity of molecules and their influence on the inhibition of HIV-1 reverse transcriptase.
Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer.
a single wild-type nucleotide is detected at position 103 of reverse transcriptase.
Detection of human respiratory syncytial virus in respiratory samples by LightCycler reverse transcriptase PCR.
A viral enzyme called reverse transcriptase (RT) converts the viral RNA into DNA.
About 10 years ago, biochemical studies in several laboratories established that AZT-resistant HIV-1 reverse transcriptase uses adenosine triphosphate, or ATP, which moves energy around inside the cell, to remove the AZT.
Intrapartum and neonatal single-dose nevirapine are commonly used and essential in the prevention of mother-to-child transmission of HIV in resource-poor settings, but may induce resistance to other non-nucleoside reverse transcriptase inhibitors.
* The FDA approves the nucleoside reverse transcriptase inhibitor (NRTI), lamivudine (Epivir, 3TC), by accelerated approval.
Roche announced in April that it would stop malting its nucleoside reverse transcriptase inhibitor Hivid (ddC) and its protease inhibitor Fortovase in 2006.
In December, Bristol-Myers Squibb and Gilead Sciences announced that they will work together to develop a fixed-dose combination of Sustiva, a non-nucleoside reverse transcriptase inhibitor ("non-nuke"), and Truvada, a combination pill containing the nucleoside reverse transcriptase inhibitor ("nuke") Emtriva and the nucleotide reverse transcriptase inhibitor Viread.
SPD754, a nucleoside reverse transcriptase inhibitor (NRTi), has already successfully completed a Phase IIa trial in 63 HIV-infected patients.
A key element in the design of these drugs is the use of flexible molecules, so that they can fit into different shapes of the "active pocket" of the reverse transcriptase enzyme, even after that shape changes due to resistance mutations that could make non-flexible molecules ineffective.

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