retroviral vector

ret·ro·vi·ral vec·tor

a specially constructed retrovirus containing one or more genes to correct certain genetic disorders.
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References in periodicals archive ?
Another inherited immune disorder, ADA deficiency has been successfully treated with a retroviral vector that delivers a functional copy of the ADA gene.
A new era: advances in gene therapy treatment
The MazF retroviral vector for this study is manufactured at the GMP compliant Center for Cell and Gene Therapy Facility of Takara Bio (Kusatsu, Shiga, Japan).
Takara Bio Initiates Phase 1 HIV Gene Therapy Clinical Trial
It is also possible to <<reprogram>> autologous T lymphocytes via transduction with a retroviral vector that carries TCRs specific for defined tumor antigens.
New cancer therapies based on the immune system
Construction of recombinant retroviral vectors and retroviral transduction: The recombinant Moloney murine leukaemia virus based retroviral vector pLTKSN was constructed as described earlier (11).
Effect of suicide gene therapy in combination with immunotherapy on antitumour immune response & tumour regression in a xenograft mouse model for head & neck squamous cell carcinoma
Inhibition of other lentiviral and retroviral vector infectivities
Dammarenolic acid, a secodammarane triterpenoid from Aglaia sp. Shows potent anti-retroviral activity in vitro
coli, is stably delivered to CD4 T cells by retroviral vector.
Takara Bio to Enter into a Collaborative Research Agreement with University of Pennsylvania, Aiming for a Future Clinical Trial of HIV Gene Therapy
In this report, a hammerhead ribozyme targeted to HIV-1 vif was designed and cloned into the retroviral vector, pSuper.
Downregulation of HIV-1 vif by a hammerhead ribozyme expressed from a retroviral vector
Germ-line transmission of pseudotyped retroviral vector in chicken.
Avian somitic cell chimeras using surrogate eggshell technology
Methods: We have transduced A549 cells to express hOgg1 using the retroviral vector pSF91 for studying the signaling transduction of MAPK.
DNA repair proteins modulate mitogen-activated protein kinase during hyperoxia
In that trial, which tested the use of a retroviral vector to treat patients with X-SCID, immune function was restored in most patients.
Guest editorial: the promise of gene therapy
Analysis of Testes and Semen from Rabbits Treated by Intravenous Injection with a Retroviral Vector Encoding the Human Factor VIII Gene: No Evidence of Germ Line Transduction," Human Gene Therapy 11, no.
The risks of germline gene transfer. (another voice)
The application of an efficient retroviral vector serves as an important tool in gene therapy and genetic analysis of a variety of genes.
Retroviral-mediated transfer and expression of the neomycin and hygromycin B drug resistance genes. (Abstract)

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