retroviral vector

ret·ro·vi·ral vec·tor

a specially constructed retrovirus containing one or more genes to correct certain genetic disorders.
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The retroviral vector backbone used in this study, pRUF-IRES-GFP, is a Murine Leukemia Virus-Based Vector which utilizes a MLV long terminal repeat (LTR).
Ectopic Expression of Human DPPA2 Gene in ESCC Cell Line Using Retroviral System
Replication competent avian leukokosis virus long terminal repeat with a splice acceptor (RCAS) is a replication-competent retroviral vector system that allows in ovo sustained misexpression of a gene of interest.
1st INEXO Symposium: Alternative models in vitro, ex ovo and organisms: From research to applications in pathologies and aging
Genotyping analysis of the DNA extracted from the tail of chimera embryos revealed that 3 out of 10 embryos at E17.5 harbored Oct4-EGFP and Cre transgenes as well as sequences of retroviral vector carrying Oct4, Sox2, and Klf4 genes (Figure 4(d)).
Reprogramming of Mouse Calvarial Osteoblasts into Induced Pluripotent Stem Cells
Klatzmann, "Replication-competent vectors and empty virus-like particles: new retroviral vector designs for cancer gene therapy or vaccines," Molecular Therapy, vol.
Viral and Nonviral Engineering of Natural Killer Cells as Emerging Adoptive Cancer Immunotherapies
Another inherited immune disorder, ADA deficiency has been successfully treated with a retroviral vector that delivers a functional copy of the ADA gene.
A new era: advances in gene therapy treatment
pBABE, a retroviral vector; hPPE, human proenkephalin; hBMSCs, human bone marrow stem cells; pBABE-hBMSCs, the pBABE-hBMSC group; hPPE-hBMSCs, the hPPE-hBMSC group.
Antinociceptive Effect of Intrathecal Injection of Genetically Engineered Human Bone Marrow Stem Cells Expressing the Human Proenkephalin Gene in a Rat Model of Bone Cancer Pain
The MazF retroviral vector for this study is manufactured at the GMP compliant Center for Cell and Gene Therapy Facility of Takara Bio (Kusatsu, Shiga, Japan).
Takara Bio Initiates Phase 1 HIV Gene Therapy Clinical Trial
It is also possible to <<reprogram>> autologous T lymphocytes via transduction with a retroviral vector that carries TCRs specific for defined tumor antigens.
New cancer therapies based on the immune system
"Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells".
Cuestionamientos eticos relacionados con la terapia genica para el tratamiento de enfermedades hereditarias
Construction of recombinant retroviral vectors and retroviral transduction: The recombinant Moloney murine leukaemia virus based retroviral vector pLTKSN was constructed as described earlier (11).
Effect of suicide gene therapy in combination with immunotherapy on antitumour immune response & tumour regression in a xenograft mouse model for head & neck squamous cell carcinoma
Inhibition of other lentiviral and retroviral vector infectivities
Dammarenolic acid, a secodammarane triterpenoid from Aglaia sp. Shows potent anti-retroviral activity in vitro
coli, is stably delivered to CD4 T cells by retroviral vector. We have demonstrated that human T cells transduced with MazF can significantly inhibit replication of HIV in vitro, while not affecting cell growth.
Takara Bio to Enter into a Collaborative Research Agreement with University of Pennsylvania, Aiming for a Future Clinical Trial of HIV Gene Therapy

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