Another inherited immune disorder, ADA deficiency has been successfully treated with a retroviral vector
that delivers a functional copy of the ADA gene.
The MazF retroviral vector
for this study is manufactured at the GMP compliant Center for Cell and Gene Therapy Facility of Takara Bio (Kusatsu, Shiga, Japan).
It is also possible to <<reprogram>> autologous T lymphocytes via transduction with a retroviral vector
that carries TCRs specific for defined tumor antigens.
Construction of recombinant retroviral vectors
and retroviral transduction: The recombinant Moloney murine leukaemia virus based retroviral vector
pLTKSN was constructed as described earlier (11).
Inhibition of other lentiviral and retroviral vector
coli, is stably delivered to CD4 T cells by retroviral vector
In this report, a hammerhead ribozyme targeted to HIV-1 vif was designed and cloned into the retroviral vector
Germ-line transmission of pseudotyped retroviral vector
Methods: We have transduced A549 cells to express hOgg1 using the retroviral vector
pSF91 for studying the signaling transduction of MAPK.
In that trial, which tested the use of a retroviral vector
to treat patients with X-SCID, immune function was restored in most patients.
Analysis of Testes and Semen from Rabbits Treated by Intravenous Injection with a Retroviral Vector
Encoding the Human Factor VIII Gene: No Evidence of Germ Line Transduction," Human Gene Therapy 11, no.
The application of an efficient retroviral vector
serves as an important tool in gene therapy and genetic analysis of a variety of genes.