retroviral vector

ret·ro·vi·ral vec·tor

a specially constructed retrovirus containing one or more genes to correct certain genetic disorders.
References in periodicals archive ?
The MazF retroviral vector for this study is manufactured at the GMP compliant Center for Cell and Gene Therapy Facility of Takara Bio (Kusatsu, Shiga, Japan).
Construction of recombinant retroviral vectors and retroviral transduction: The recombinant Moloney murine leukaemia virus based retroviral vector pLTKSN was constructed as described earlier (11).
In this report, a hammerhead ribozyme targeted to HIV-1 vif was designed and cloned into the retroviral vector, pSuper.
Methods: We have transduced A549 cells to express hOgg1 using the retroviral vector pSF91 for studying the signaling transduction of MAPK.
In that trial, which tested the use of a retroviral vector to treat patients with X-SCID, immune function was restored in most patients.
Analysis of Testes and Semen from Rabbits Treated by Intravenous Injection with a Retroviral Vector Encoding the Human Factor VIII Gene: No Evidence of Germ Line Transduction," Human Gene Therapy 11, no.
The application of an efficient retroviral vector serves as an important tool in gene therapy and genetic analysis of a variety of genes.
June, MD, Professor of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine, and has now completed a series of preparations such as; preclinical translational studies, GMP manufacturing of MazF retroviral vector, GMP manufacturing of MazF-transduced CD4+ T cells, and has finally submitted the documents for the IND application.
For initial cell culture testing, Tat5910 and its non-catalytic control Tat5910[DELTA], were subcloned into the retroviral vector pSuper.
The cells were transduced using a Moloney leukemia virus-derived retroviral vector that expressed the normal full-length LAMB3 gene found to contain a single point mutation in the patient's genetic profile (Nat.