As a model of retrograde degeneration
, the L4-L5 ventral rhizotomy is similar to axotomy paradigms in the CNS, in which loss of differentiated transmitter phenotype (usually an early change) is accompanied by alterations in the neuronal cytoskeleton and, eventually, cell death (Gage et al., 1986; Koliatsos et al., 1989).
Because RD increases are primarily caused by demyelination [40, 41], our findings are strongly suggestive of demyelination caused by secondary Wallerian degeneration or retrograde degeneration after SCI.
Hepp Reymond, "Retrograde degeneration of the pyramidal tract cells in the motor cortex of apes (Macaca fascicularis)," Acta Anatomica, vol.
An important prerequisite for axonal regeneration would be the prevention of retrograde degeneration
that could cause neuronal death or atrophy impeding the activation of axonal regrowth.
It is inferred that retrograde degeneration
of nerve cell is a new form of cell death in "tau disease" such as AD (Kaminska et al.
In untreated brain injury, not only do brain cells die in the injured area, but nerve cells in other brain regions connected by nerve fibers to the injured area also die by a process known as retrograde degeneration
Nerve conduction is interrupted and the nerve fiber undergoes retrograde degeneration