retinol dehydrogenase

ret·i·nol de·hy·dro·gen·ase

an oxidoreductase catalyzing interconversion of retinal and NADH to retinol and NAD+.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 4q23-q24 that encodes class-IV alcohol dehydrogenase 7 mu or sigma subunit, which like other alcohol dehydrogenases metabolises various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. ADH7 is inefficient in ethanol oxidation; it is the most active as a retinol dehydrogenase and may participate in synthesising retinoic acid—which is required for cellular differentiation. ADH7 is highly expressed in the stomach.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ret·i·nol de·hy·dro·gen·ase

(ret'i-nol dē'hī-droj'ĕn-ās)
An oxidoreductase-catalyzing interconversion of retinal and NADH to retinol and NAD+.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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References in periodicals archive ?
In rat's brain, microsomal [NAD.sup.+]-dependent retinol dehydrogenase 2 (RDH2) catalyzes the reverse reaction of ALLO or DIOL back to dihydroprogesterone and dihydrotestosterone, thus controlling the levels of these neurosteroids [12] (Scheme 2).
Abbreviations 3[alpha]-HSD: 3[alpha]-Hydroxysteroid dehydrogenase ALLO: Allopregnanolone DHT: Dihydrotestosterone DIOL: Androstanediol [IC.sub.50]: Half maximum inhibitory concentrations RDH2: Retinol dehydrogenase 2 5[alpha]-Red1: 5[alpha]-Reductase 1 TEB: Tebuconazole T: Testosterone TRI: Triadimefon VCZ: Vinclozolin.
Napoli, "Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III," Gene, vol.
Once inside the target cell, retinol is converted into retinaldehyde by a retinol dehydrogenase (ROLDH), which in turn is converted to ATRA by retinaldehyde dehydrogenase (RALDH).