Prescriptions for topical retinoids
, a first-line topical agent, increased fivefold.
also make the skin more sensitive to the sun.
"Today's FDA approval of ALTRENO builds upon our strong acne portfolio, providing physicians and patients a trusted retinoid
in a lotion formulated to enhance the user's experience with the inclusion of moisturizing attributes of hyaluronic acid, glycerin and collagen," said Bill Humphries, president, Ortho Dermatologics.
In addition to discussing the implications of the FDA's unprecedented approval of a full prescription-strength topical retinoid
for OTC use, highlighted other developments in topical therapy for acne, including the 2016 approval of dapsone 7.5 percent gel, as well as several agents with novel mechanisms of action now ending their way through the developmental pipeline.
Retinol, a form of retinoid
, is a type of vitamin A.
Recommended by the experts The Ordinary Advanced Retinoid
2%, PS8 from Asos Indeed Labs Retinol Reface Retinol Skin Resurfacer 30ml, PS19.99 La Roche-Posay Redermic Anti-Ageing Concentrate Intense, PS29.50
Methods used include the following: emollients, keratolytics, topical 5-fluorouracil, topical vitamin D3 analogues, topical retinoids
, oral retinoids
, cryotherapy, surgical methods and laser treatment .
There have been reports on the use of topical agents such as corticosteroids and vitamin D derivates, vitamin A, photo(chemo)therapy, and systemic therapies such as systemic retinoids
, azathioprine, methotrexate, cyclosporine, and biological agents (6, 7).
are naturally occurring and synthetic analogues of vitamin A which is essential for embryogenesis growth and epithelial differentiation.1Maternal vitamin A deficiency or retinoic acid (RA) excess results in a spectrum of congenital malformations in a dose and developmental stage dependentmanner.23 Thus RA levels must be strictly controlled and should be consumed with caution during pregnancy.The effects of RA are mediated by two major groups of peptides the nuclear receptor proteins and the cytoplasmic binding proteins.
Various treatment modalities like topical 5-fluorouracil, calcipotriol, retinoids
and oral retinoids
are found to be effective along with surgical procedures like cryotherapy, dermabrasion and CO2 laser ablasion.5 The patient is treated here with topical retinoids
and sun protective measures.
profoundly alter the differentiation pattern of human epidermal keratinocytes, but the underlying biochemical basis of this change is not known.
When selecting products, look for options that contain retinoids
, such as retinol, retinyl, or retinoic add.