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Inadequate levels of retinoids (excess or deficiency) may result in a set of defects denoted retinoic acid embryopathy which may provoke defects in the development of the neural crista (Kam et al., 2012).
Retinoic acid embryopathy. N Engl J Med 1985; 313: 837-41.
Inadvertent use of 13-cis-retinoic acid during the first trimester of human pregnancy has been reported to result in a spectrum of malformations termed retinoic acid embryopathy (RAE) (20) and includes microtia or anotia, micrognathia and in some cases CP.

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