retinoic acid embryopathy

retinoic acid embryopathy

characteristic pattern of mental and physical birth defects that results from maternal use of retinoids, the synthetic derivatives of vitamin A, during pregnancy. The most well known retinoid is isotretinoin, a drug used to treat severe cystic acne. Features may include growth delays, malformations of the skull and facial region, and central nervous system and cardiac abnormalities.

retinoic acid embryopathy

Perinatology A teratogenic complex induced by retinoic acid, a vitamin A analogue, resulting in a 26-fold ↑ of congenital defects–eg, microtia, anotia, cleft palate, cardiac–conotruncal and aortic arch, neural crest, craniofacial, thymic defects, hyperostoses, retinal and optic nerve abnormalities, CNS malformations, premature closure of the epiphyseal plates; an identical embryopathy occurs with 'megadose' ingestion of vitamin A
References in periodicals archive ?
Inadequate levels of retinoids (excess or deficiency) may result in a set of defects denoted retinoic acid embryopathy which may provoke defects in the development of the neural crista (Kam et al., 2012).
Retinoic acid embryopathy. N Engl J Med 1985; 313: 837-41.
Inadvertent use of 13-cis-retinoic acid during the first trimester of human pregnancy has been reported to result in a spectrum of malformations termed retinoic acid embryopathy (RAE) (20) and includes microtia or anotia, micrognathia and in some cases CP.

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