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Inadvertent use of 13-cis-retinoic acid during the first trimester of human pregnancy has been reported to result in a spectrum of malformations termed retinoic acid embryopathy (RAE) (20) and includes microtia or anotia, micrognathia and in some cases CP.
Lammar EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, Curry CJ, Fernhoff PM, Grix AW, Lott IT, Richard JM, Sun SC: Retinoic acid embryopathy.

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