retinoic acid


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Related to retinoic acid: vitamin A

retinoic acid

 [ret″ĭ-no´ik]
an oxidized derivative of retinol, believed to be the form of vitamin A that plays a role in the development and growth of bone and in the maintenance of normal epithelial structures. The all-trans isomer is called tretinoin and used as a keratolytic and antineoplastic agent. The 13-cis isomer is called isotretinoin and used as a treatment for acne.

ret·i·no·ic ac·id

(ret'i-nō'ik as'id),
Vitamin A1 acid; used topically to treat acne.
Synonym(s): vitamin A1 acid

retinoic acid

(rĕt′n-ō′ĭk)
n.
1. A vitamin A derivative, C20H28O2, that serves as a regulator of morphogenesis and functions in the growth and development of bone and the maintenance of epithelium.
2. Either of two isomers of this compound, tretinoin or isotretinoin, that are used as drugs chiefly to treat acne. In both senses also called vitamin A acid.

(all-trans-)retinoic acid

Tretinoin The natural form of vitamin A, which transports monosaccharides in glycoprotein synthesis, as occurs in the turnover of mucosal epithelia of the oral cavity, respiratory and urinary tracts. See Retinal, Retinoic acid embryopathy, Tretinoin, Vitamin A.

ret·i·no·ic ac·id

(ret'i-nō'ik as'id)
Retinaldehyde in which the terminal -CHO has been oxidized to a -COOH; used topically in the treatment of acne; plays an important role in growth and differentiation.
Synonym(s): vitamin A1 acid.

Retinoic acid

Vitamin A1 acid which is used topically to treat acne.
Mentioned in: Warts

ret·i·no·ic ac·id

(ret'i-nō'ik as'id)
Agent used topically to treat acne.
Synonym(s): vitamin A1 acid.

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References in periodicals archive ?
Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice.
Intravenous fluid treatment, empiric antibiotic treatment and retinoic acid treatment at a dosage of 1 mg/kg/day was initiated.
These cells are subdivided into the following three main groups: group 1 ILCs (ILC1), which include natural killer (NK) cells, are induced by transcription factor T-box expressed in T cells (T-bet) and produce IFN-[gamma]; ILC2 require the GATA-binding protein 3 (GATA3) transcription factor and produce IL-5 and IL-13; and ILC3 depend on the transcription factor retinoic acid receptor-related orphan nuclear receptor gamma (ROR[gamma]t) and secrete IL-17 and IL-22 [69].
Lu et al., "All-trans retinoic acid favors the development and function of regulatory T cells from liver transplant patients," International Immunopharmacology, vol.
Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldhtat) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid. J Biol Chem 2003;278:36085-90.
Function of retinoic acid receptors during embryonic development.
Redifferentiation therapy of differentiated thyroid carcinoma with retinoic acid: basics and first clinical results.
The results of the study demonstrated that when compared to the control, a 5% retinoic acid peel combined with microdermabrasion can result in clinically and statistically significant improvements in multiple aspects of facial photo-damage (Figure 1).
[11] described a fusion product between a novel zinc finger gene and the retinoic acid receptor with t(11;17)(q23;q21) in a patient with APL.
(4,5) Both PML and RARA have a role in normal hematopoiesis, with PML having both growth suppressor and proapoptotic activity and RARA functioning as a transcription factor that mediates the effect of retinoic acid, which is necessary for normal myeloid maturation, at specific response elements.
To interact with retinoid receptors, retinol must first be metabolized to more active forms, such as retinaldehyde and retinoic acid using several enzymatic steps.

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