A key step in retinoid metabolism occurs with help from an enzyme called retinaldehyde dehydrogenase
1, or Aldh1a1.
KEY WORDS: AHR, cleft, mesenchyme, mouse, nasal epithelium, RAR, retinaldehyde dehydrogenase (RALDH), teratogenesis, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment.
Once inside the target cell, retinol is converted into retinaldehyde by a retinol dehydrogenase (ROLDH), which in turn is converted to ATRA by retinaldehyde dehydrogenase
Researchers at the Hebrew University in Israel have found that shutting down a molecule needed to produce retinoic acid, known as retinaldehyde dehydrogenase
(RALDH2), increases sensitivity of developing embryos to low doses of alcohol.
And retinaldehyde dehydrogenases
(RALDH) oxidize retinaldehyde to retinoic acid, primarily by RADLH1 .