A key step in retinoid metabolism occurs with help from an enzyme called retinaldehyde dehydrogenase
1, or Aldh1a1.
KEY WORDS: AHR, cleft, mesenchyme, mouse, nasal epithelium, RAR, retinaldehyde dehydrogenase (RALDH), teratogenesis, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment.
Once inside the target cell, retinol is converted into retinaldehyde by a retinol dehydrogenase (ROLDH), which in turn is converted to ATRA by retinaldehyde dehydrogenase
a company harnessing breakthroughs in brown fat biology and insulin sensitization to revolutionize the treatment of metabolic disease, today announced that it has secured exclusive option rights to intellectual property for three key small molecule targets - retinaldehyde dehydrogenase
1 (Aldh1a1), thioesterase superfamily member 1 (Them1), and TRPV4.
Researchers at the Hebrew University in Israel have found that shutting down a molecule needed to produce retinoic acid, known as retinaldehyde dehydrogenase
(RALDH2), increases sensitivity of developing embryos to low doses of alcohol.