retinal pigment epithelium


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Related to retinal pigment epithelium: retinitis pigmentosa, retinal detachment

retinal pigment epithelium (RPE) 

A brown monolayer of cells of the retina situated next to the choroid composed of cells joined by tight junctions and filled with pigment, mainly melanin and lipofuscin (Fig. R9). Depending upon the amount of pigment, the fundus will appear dark or light. The main functions of the RPE are: control of the flow of fluid and nutrients entering the retina (blood-retina barrier), absorption of scattered light, visual pigment metabolism, vitamin A metabolism which contributes to visual pigment regeneration, ingestion and digestion of photoreceptor discs (phagocytosis), retinal adhesion and synthesis of growth factors of adjacent tissues. A dysfunction of this tissue can be detected with the electrooculogram. See Bruch's membrane; Usher's syndrome.
Fig. R9 Schematic representation of the cells and layers of the central primate retina (1: retinal pigment epithelium; 2: layer of rods and cones; 3: external limiting membrane; 4: outer nuclear layer; 5: outer plexiform layer; 6: inner nuclear layer; 7: inner plexiform layer; 8: ganglion cell layer; 9: nerve fibre layer; 10: internal limiting membrane)enlarge picture
Fig. R9  Schematic representation of the cells and layers of the central primate retina (1: retinal pigment epithelium; 2: layer of rods and cones; 3: external limiting membrane; 4: outer nuclear layer; 5: outer plexiform layer; 6: inner nuclear layer; 7: inner plexiform layer; 8: ganglion cell layer; 9: nerve fibre layer; 10: internal limiting membrane)
References in periodicals archive ?
King, "Microarray analysis of gene expression in West Nile virus-infected human retinal pigment epithelium," Molecular Vision, vol.
Lu et al., "A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer," Ophthalmic Research, vol.
Pius-Sadowska et al., "Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair," Experimental Eye Research, vol.
Total macular thickness was recorded as the distance between superior border of retinal pigment epithelium and superior border of detached neurosensory retina at the Centre of macula.
Rizzolo, "Development and role of tight junctions in the retinal pigment epithelium," International Review of Cytology, vol.
3), or between the retinal pigment epithelium (RPE) and the sensory retina.
The internal structures were disorganized with diffuse calcification and bone formation at the level of the retinal pigment epithelium and choroid.
With the financing, Advanced Cell will be able to advance its retinal pigment epithelium cells program.
Geography atrophy appears as confluent regions of cell death in photoreceptors and in the retinal pigment epithelium, according to the report in the August 27th online issue of The New England Journal of Medicine.
"She suffered commotioretinae (reduced vision caused by trauma) with damage to the retinal pigment epithelium (a layer of cells in the eye) and macular hole formation (the creation of a hole in the macula, which is part of the retina)."
During a mean of 12 years, there were 549 cases of ARM, including 332 cases of visually significant ARM, two-thirds of which had a combination of drusen and retinal pigment epithelium changes when visual acuity was first noted to be 20/30 or worse.
Key words: age-related macular degeneration, aged retinal pigment epithelium, bovine corneal endothelial cell extracellular matrix, cell migration, cell proliferation, choroidal neovascularization, extracellular matrix, fetal retinal pigment epithelium, retinal pigment epithelium resurfacing, wound healing.