The scientists discovered that a key component of the cells lining the retinal blood vessels
, namely claudin-5, may be central to the development of the common blinding eye disease, AMD.
In some people with diabetic retinopathy, retinal blood vessels
may swell and leak fluid.
They found that the Alzheimer's group had retinal thinning and had lost small retinal blood vessels
at the back of the eye.
Diabetic retinopathy is a common complication of diabetes and involves changes in retinal blood vessels
. In some people with diabetic retinopathy, blood vessels may swell and leak fluid.
Diabetic retinopathy involves changes to the retinal blood vessels
that can cause them to bleed or leak fluid, impairing vision.
"After comparing cardiovascular risk factors with the size and shape of retinal blood vessels
, we were able to show that ideal cardiovascular health in childhood, and improvement a to mid-adulthood, appear to have a protective effect on the retinal microvasculature," said Dr.
AngioAnalytics brings objective data and analysis to Optovue's AngioVue OCTA technology which allows for high-resolution imaging of retinal blood vessels
to create color-encoded maps of the vessel densities of the retina or optic nerve, and provide analyses of areas where there is blood vessel loss, abnormal blood vessel growth, or change to the foveal avascular zone.
"Our study presents an unexpected finding that the connections between cells in the retinal blood vessels
contain unusual, long-chain lipids that may keep vessels from leaking, possibly preventing diabetic retinopathy from occurring," said lead author Julia Busik.
Williamson, "Automated localisation of the optic disc, fovea, and retinal blood vessels
from digital colour fundus images," Journal of Medical Genetics, vol.
Furthermore, image analysis provides a simple and noninvasive visualization of the retinal blood vessels
in those high risk ophthalmologic medical conditions [1-3].
In the mouse retina, superficial retinal blood vessels
start growing rapidly from the optic nerve head toward retinal periphery at birth, and by postnatal day 3 (P3), approximately 30% of the retina is covered by vascular network (Figure 2(a)), and by P6, approximately 70% is covered by vessels (Figure 2(b)), and retinal vascularization is completed by P8.
"Alterations in blood glucose levels in diabetes cause changes in retinal blood vessels
which swell, bleed or leak fluid into the back of the eye," said senior study author Ecosse Lamoureux of the Singapore Eye Research Institute and the Duke-NUS Medical School in Singapore.