Many studies have found iron deposition in the liver,[sup],,,, and in both hepatocytes and reticuloendothelial cells
.[sup],, Di Bisceglie et al .[sup] were the first to find elevated serum ferritin and iron levels in patients with chronic hepatitis (both chronic hepatitis B and CHC).
Tf incorporates iron coming from two major sources: dietary iron (both inorganic and heme iron) absorbed in the duodenum to compensate for daily iron loss and iron derived from destruction of old and effete erythrocytes by reticuloendothelial cells
in the spleen and liver (Figure 3).
The vascular endothelium and reticuloendothelial cells
in vertebrates, including humans, are infected by them.
the cardiopulmonary junction).32 Also as a paramagnetic material accumulating in haemorrhagic infarction disease haemoglobin shows low signal on T2 weighted imaging.33 It is important to note that with the death and rupture of transplanted cells targeted SPIO nanoparticles can be phagocytosed by surrounding tissue cells or reticuloendothelial cells
and subsequently redistributed deposited or differentiated.
In Fabry's Disease deficiency of lysosomal enzyme a-galacto sidase A9 results in progressive accumulation of neutral glycosphingolipids with terminal a-galactosyl residue (ceramide di and tri hexoside) in lysosomes of endothelial, epithelial, smooth muscle cells, myocardial cells, nephrons, reticuloendothelial cells
, connective tissue, corneal epithelial cells, ganglia and perineural cells of autonomic nervous system.
The ingested yeasts multiply inside the macrophages and are spread throughout the body via the lymphatics during the preimmune phase of the illness to organs rich in reticuloendothelial cells
Histopathology of biopsy material revealed a mixture of large number of reticuloendothelial cells
, medium and large lymphoid cells with rounded nucleus and small nucleoli and many cells with irregular nuclei suggestive of lymphosarcoma as reported by De Bruijn et al.